In complex clinical trials, multiple research objectives are often grouped into sets of objectives based on their inherent hierarchical relationships. Consequently, the hypotheses formulated to address these objectives are grouped into ordered families of hypotheses and thus to be tested in a pre-defined sequence. In this paper, we introduce a novel Bonferroni based multiple testing procedure f...

1 Introduction and Overview Many problems in combinatorics, number theory, probability theory, reliability theory and statistics can be solved by applying a unifying method, which is known as the principle of inclusion-exclusion. The principle of inclusion-exclusion expresses the indicator function of a union of finitely many sets as an alternating sum of indicator functions of their intersecti...