Cell therapy using stem cell transplantation against cerebral ischemia has been reported. However, it remains controversial regarding the optimal time for cell transplantation and the transplantation route. Rat models of cerebral ischemia were established by occlusion of the middle cerebral artery. At 1, 12 hours, 1, 3, 5 and 7 days after cerebral ischemia, bone marrow mesenchymal stem cells we...

1. Weiden PL, Sullivan KM, Flournoy N, Storb R, Thomas ED. Antileukemic effect of chronic graft-versus-host disease: contribution to improved survival after allogeneic marrow transplantation. N Engl J Med 1981; 304:1529-33. 2. Horowitz MM, Gale RP, Sondel PM, Goldman JM, Kersey J, Kolb HJ, et al. Graft-versus-leukemia reactions after bone marrow transplantation. Blood 1990; 75:555-62. 3. Russel...

Cardiovascular disease remains the leading cause of morbidity and mortality in the United States and Europe. In recent years, the understanding that regenerative processes exist at the level of the myocardium, has placed stem cell research at center stage in cardiology. A stem cell is a cell that has the ability to divide (self replicate) for indefinite periods often throughout the life of the ...

introduction: as an inherited neurodegenerative disease, huntington's disease is accompanied with wide neuronal degeneration in neostriatum and neocortex. progress of the disease causes disabling clinical effects on movements, recognition and physiology of the body, and finally results in death. at this stage of knowledge we are, there is no effective therapeutic strategy for diminishing t...

Background Chronic allograft nephropathy(CAN)  is one of the most common causes of chronic and end stage renal disease. It  is defined with Mainly tubular atrophy and  interstitial fibrosis and no evidence of any other etiology, or functional disorder that caused at least three months after transplantation . Control of risk factors (HTN,DM,HLP, …) and limiting  usage of calcineurin inhibitors...

objective(s):the application of stem cells holds great promises in cell transplants. considering the lack of optimal in vitro model for hepatogenic differentiation, this study was designed to examine the effects of laminin matrix on the improvement of in vitro differentiation of human bone marrow mesenchymal stem cells (hbm-msc) into the more functional hepatocyte-like cells. materials and meth...

background: the aim of this study was optimization of the polyfect gene delivery method of pcdna3.1 expression vector transfected with the mouse pdx-1 gene in three different kinds of mesenchymal stem cells and hepa cells as well as comparison of transfection efficiency leading to expression of the mentioned gene in the cell types used. materials and methods: rat bone marrow-derived mesenchymal...

background: dendritic cells (dcs) are the most potent stimulators of primary t cell responses and play a key role in immune reactions after stem cell transplantation. very little is known about the cord blood (cb) dendritic cells and their potential involvement in the low incidence and lower severity of acute graft-versus-host disease after cb transplantation.   objectives: the aim of this stud...

introduction: the majority of leukemia patients are acute leukemia patients, so that about 70.8% lymphoblastic leukemia were acute lymphoblastic leukemia (all) patients and 66.4 % of myeloid leukemia patients were acute myeloid leukemia (aml) in tehran metropolitan. during the last two decades, intensification of therapy by the use of high-dose cytarabine allogeneic stem cell transplantation in...