نتایج جستجو برای: bone marrow micronucleus assay

تعداد نتایج: 525765  

2016
Reza Ghasemnezhad Targhi Vahid Changizi Farhang Haddad Mansour Homayoun Shokouhozaman Soleymanifard

OBJECTIVE Ionizing radiation produces free radicals which induce DNA damage and cell death. Origanum vulgare leaf extract (OVLE) is a natural compound and its capability of scavenging free radicals and its antioxidant activity have been demonstrated by many researchers. In this study, using micronucleus assay, radioprotective effect of OVLE against clastogenic and cytotoxic effect of gamma irra...

Journal: :Folia Histochemica Et Cytobiologica 2021

Introduction. In our previous study, it has been confirmed that formaldehyde (FA) not only inhibits the proliferative activity, but also causes DNA-protein crosslinks (DPCs) formation in bone marrow mesenchymal stem cells (BMSCs). The purpose of this study was to detect protective effect astragalus polysaccharide (APS) against cytotoxicity and genotoxicity BMSCs exposed FA, explore potential mo...

2013
Mohammad Shokrzadeh Aroona Chabra Farshad Naghshvar Amirhossein Ahmadi

Possible genoprotective effect of Citrullus colocynthis (L.) (CCT) fruits extract against cyclophosphamide- (CP-)induced DNA damage in mice bone marrow cells was evaluated using micronucleus assay, as an index of induced chromosomal damage. Mice were preadministered with different doses of CCT via intraperitoneal injection for 7 consecutive days followed by injection with CP (70 mg/kg b.w.) 1 h...

مزدارانی, حسین,

An . in vivo micronucleus assay using mouse bone marrow for identifying radioprotective effect of cimetidine is described. The influence of cimetidine, an antagonist to histamine H2 receptor, on the kinetics of low and high LET radiations such as gamma rays and neutron induced micronuclei as well as the clastogenic effects of chemicals such as benzene, ara C and mitomycin C was tested in Swiss ...

Journal: :Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2015
Laura-Ana Corcuera Ariane Vettorazzi Leire Arbillaga Noemí Pérez Ana Gloria Gil Amaya Azqueta Elena González-Peñas Jose Antonio García-Jalón Adela López de Cerain

Aflatoxin B1 (AFB1) and Ochratoxin A (OTA) are genotoxic mycotoxins that can contaminate a variety of foodstuffs, the liver and the kidney being their target organs, respectively. The micronucleus (MN) assay (bone marrow) and the comet assay (liver and kidney) were performed simultaneously in F344 rats, treated with AFB1 (0.25 mg/kg b.w.), OTA (0.5 mg/kg b.w.) or both mycotoxins. After AFB1 tre...

Journal: :Environmental Health Perspectives 1994
M Hayashi S Hashimoto Y Sakamoto C Hamada T Sofuni I Yoshimura

To evaluate chemical safety, many kinds of short-term mutagenicity assays are performed together with long-term assays in animals. Rationales and methodology for these assays have been well discussed and documented. No statistical method, however, has been singled out as the method of choice for the evaluation of mutagenicity assay data, although a number of reports on statistical methods to ev...

2017
Jun-Won Yun Yun-Soon Kim Euna Kwon Seung-Hyun Kim Ji-Ran You Hyeon Hoe Kim Jeong-Hwan Che Byeong-Cheol Kang

Among three representative species of Angelica found in Asian countries, including Korea, China, and Japan, Angelica acutiloba (AA) has been used as traditional herbal medicine with antitumor, anti-inflammatory, anti-obesity, and anti-diabetes activities. In this study, the potential genotoxicity and mutagenicity of the AA extract were examined in a battery of in vitro and in vivo tests (bacter...

Journal: :Food chemistry 2013
Mingyuan Liu Meishuo Zhang Haiqing Ye Songyi Lin Yi Yang Liying Wang Gregory Jones Hung Trang

In the present study, aberration, body weight, food consumption, haematology, organ coefficients, and both gross and microscopic appearance of some histiocytes were compared between the test and control groups. A sperm abnormality test, bone marrow cell micronucleus test, and a haematology study were conducted at levels of 1.25 g/kg, 2.5 g/kg, and 5 g/kg of trehalose. In both the sperm abnormal...

2010
Ahmad Bustamam Abdul Mohammed Yousif Siddig Ibrahim Manal Mohamed Elhassan Syam Mohan

Zerumbone (ZER) is derived from Zingiber zerumbet smith from the Zingiberaceae family. It has been shown to have anti-cancer and apoptosis-inducing properties against various human tumour cells. The aim of our study was to assess the genotoxic effects of ZER in cultured human peripheral blood lymphocytes, Chinese Hamster Ovary (CHO) cells and rat bone marrow polychromatic erythrocytes (PCEs) us...

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