although involvement of the heart by malignant lymphoma is relatively common, it is unusual to be detected premortem. we report a case of hodgkin's lymphoma who presented with systemic signs and symptoms including abdominal distension, weakness, pallor, chills and fever, hepatosplenomegaly and generalized lymphadenopathy as well as signs of heart failure. echocardiography revealed lucent myocar...

Multiple Myeloma (MM) is characterized by a clonal expansion of plasma cells in the bone marrow. These typically produce monoclonal immunoglobulin, and its symptoms arise either from cell infiltration several organs, or secondary to presence protein peak. Symptoms can be summarized acronym CRAB (hypercalcemia, renal failure, anemia lesions). Sometimes, setting secreting gammopathy, formation cr...

The usefulness of bone marrow scintigraphy with 99mTc-HMPAO-labeled leukocytes (leukocyte bone marrow scintigraphy) in the diagnosis of skeletal metastases of cancers was investigated in 70 lesions in 27 patients with various types of cancer. The final diagnosis of skeletal metastases was based on one or more criteria consisting of histological confirmation, typical findings of metastases by bo...

The blood and bone marrow smears and sections of 38 patIents with angloimmuno. blastic lymphadenopathy (AILD) were examined and their hematologic data were reviewed. A normochromic normocytic anemia was found in 84% of patients. A positive direct Coombs’ test was noted in one-third of the patients tested. Leuko.. cytosis with neutrophilia and/or eoslnophilia were observed frequently. Lympho.. c...

Cutaneous presentation revealing acute myeloid leukemia (AML) is rare, and the prognosis poor. We report a case of an 11-month-old male who presented with cutaneous lesions present as diffuse purplish papulo-nodular lesions, M5 leukemia. Skin biopsy immunohistochemical examination, combined routine blood analysis bone marrow contributed to early diagnosis. However, despite intensive chemotherap...

We used a bone marrow transplantation approach to distinguish the activities of bone marrow-derived macrophages from the activities of central nervous system-resident microglia in phenomena associated with axon demyelination and remyelination. We transplanted wild type or germline NG2 null beta-actin-EGFP expressing bone marrow into irradiated wild type or NG2 null recipient mice, followed by a...

OBJECTIVE Determinants of radiographic progression in osteoarthritis (OA) are poorly understood. We investigated which features on baseline magnetic resonance imaging (MRI) acted as predictors of change in joint space width (JSW). METHODS A total of 559 men and women over the age of 50 years with clinical knee OA [Kellgren-Lawrence (KL) grade 2-3] were recruited to the placebo arm of the SEKO...

RANULOMATOUS LESIONS have been found iii paraffin sections nlade from particles of bone marrow removed by aspiration from patients w’it-h tuberculosis, histoplasmosis, brucehlosis, sarcoidosis, infectious mononucleosis, malignant lymphomas or miscellaneous and indeterminate disorders.19 In a previous paper,4 I discussed the significance of granulomatous lesions foiits(l in sections made from bo...