objective(s) the use of co-culture cells as well as extra cellular matrix are among those strategies that have been employed to direct mesenchymal stem cell (msc) bone differentiation in culture. in this regard, there is no study considering the effects of matrigel on mesenchymal stem cell (msc) in vitro bone differentiation. this was the subject of the present study. materials and methods huma...

there has been considerable inconsistency regarding the potential relationship between dyslipidemia and bone metabolism. the inflammatory stimulation through the receptor activator of the nuclear factor kappa-b ligand (rankl)/ receptor activator of the nuclear factor kappa-b (rank)/ osteoprotegerin (opg) pathway could be the infrastructural mechanism for hypercholesterolemia-induced bone loss. ...

Multipotent human bone marrow-derived mesenchymal stem cells (hMSCs) are promising candidates for and cartilage regeneration. Toll-like receptor 4 (TLR4) is expressed by hMSCs a both exogenous endogenous danger signals. TLRs have been shown to possess functional differences based on the species (human or mouse) they isolated from therefore, effects of knockdown TLR4 were evaluated in humans dur...

Fat embolism syndrome refers to a constellation of symptoms secondary to the presence of fat globules in the lung parenchyma and/or peripheral blood circulation. The syndrome is most often seen in association with long bone or pelvic fractures and can cause significant morbidity and mortality. The present randomized double blind placebo-controlled trial was conducted to evaluate the efficacy of...

objective: osteon has been introduced as a bone substitute material. it is biphasic calcium phosphate (bcp) that use in dentistry. the aim of the present study was to evaluate the effect of osteon on the proliferation, cell viability and differentiation of saos-2 cells in vitro. also it was compared with cerasorb bone graft. materials and methods: two different bone grafts materials, osteon an...

fat embolism syndrome refers to a constellation of symptoms secondary to the presence of fat globules in the lung parenchyma and/or peripheral blood circulation. the syndrome is most often seen in association with long bone or pelvic fractures and can cause significant morbidity and mortality. the present randomized double blind placebo-controlled trial was conducted to evaluate the efficacy of...

Osteoporosis, which contributes to morbidity and mortality, often coexists with cardiovascular disease, especially atherosclerosis. We have reported recently that in vitro exposure of human T-lymphocytes to oxidized lipids induced expression of a key osteoclastogenic cytokine, receptor activator of NF-κB ligand (RANKL). Our previous studies have shown that mice fed an atherogenic high-fat diet ...

Obesity, diabetes, and osteoporosis are major public health concerns. Current estimates indicate that the US population consists of 25% obese, 30% diabetic and prediabetic, and, among the elderly, 50% of all osteoporotic individuals. Mechanistically, these pathologies share several features including common regulators of bone homeostasis and energy metabolism. Peroxisome proliferator-activated ...