This study aims to evaluate potential toxic effect of Jatropha curcas leaves methanol extract on laboratory rats as well as determine its LD50. A total of 80 male Wistar rats were used as the experimental animals, 40 for LD50 determination and the other 40 for toxicity study. Based on the pretest that was done in order to establish a range of toxicity, 4 dosages (86.00, 58.00, 46.00, and 34.0 k...

Evidence suggests that individuals have become more tolerant of higher body weights over time. To investigate this issue further, the authors examined cross-sectional associations among ideal weight, examination year, and obesity as well as the association of ideal weight and body weight satisfaction with health practices among 15,221 men and 4,126 women in the United States. Participants in 19...

BACKGROUND & AIMS Mechanisms underlying weight loss maintenance after gastric bypass are poorly understood. Our aim was to examine the effects of gastric bypass on energy expenditure in rats. METHODS Thirty diet-induced obese male Wistar rats underwent either gastric bypass (n = 14), sham-operation ad libitum fed (n = 8), or sham-operation body weight-matched (n = 8). Energy expenditure was m...

Eighteen replicates (9 barrows, 9 gilts) were used to estimate the dietary available phosphorus (AP) needs of a high lean strain of pigs during each of four stages of growth (9 to 37, 37 to 65, 65 to 92, and 92 to 119 kg body weight [BW]). Pigs were self-fed a basal diet supplemented with one of six incremental additions of AP from monodicalcium phosphate. Initially (9 to 37 kg), pigs were fed ...

The composition of weight change has a large impact on energy balance calculations. Composition of long-term weight change interventions is well-documented, but information on short-term weight change under unrestricted free-living conditions is limited. The composition and energy density of the changes in body weight during 2-week free-living conditions were analyzed in adults from two cohorts...

BACKGROUND Despite the well-known recidivism of obesity, surprisingly little is known about the composition of body weight during weight regain. OBJECTIVE The objective of this study was to determine whether the composition of body weight regained after intentional weight loss is similar to the composition of body weight lost. DESIGN The design was a follow-up to a randomized controlled tri...

The relation between relative weight and health differs between young and old. In older populations, weight change may cloud the association between a single relative weight and health outcomes. To determine whether weight or weight change is a more important determinant of mortality in a population of older adults, the authors analyzed data from the Systolic Hypertension in the Elderly Program...

Purpose: The seeds of Swietenia macrophylla are used in traditional medicine for the treatment of diarrhoea. Thus the petroleum ether extract of Swietenia macrophylla (Meliaceae) seeds was investigated for its anti-diarrhoeal property in Wister albino rats to substantiate folklore claim. Methods: Petroleum ether extract of the seeds of this plant, at graded doses (25, 50 & 100mg/kg body weight)...

BACKGROUND The present study was undertaken to study the effect of mercuric chloride (HgCl2) on the collagen metabolism in rats and the protective effect of 2, 3-dimercapto-1-propane sulfonic acid (DMPS) in HgCl2-treated rats. MATERIAL/METHODS The experimental groups studied were (i) a control group (ii) rats injected with a single intraperitoneal (ip) dose of 2 mg of HgCl2/kg body weight (Hg...

Pancreatic islet cell tumors were induced in 38 of 44 male Wistar rats (86%), which survived 9 to 14 months following the various treatment schedules. A single i.v. injection of streptozotocin alone, 30, 40, 50, or 65 mg/kg of body weight produced adenomas of pancreatic islet cells in 8 of 9 (89%), 6 of 7 (86%), 2 of 4 (50%), and 1 of 2 rats (50%), respectively. The neoplasms were seen in all o...