Endocrine function was assessed in 31 children (17 boys) after fractionated total body irradiation used in the preparative regimen for bone marrow transplantation. Endocrine dysfunction was present in 25 children. Fifteen of 29 had growth hormone insufficiency 0.9-4.9 years after total body irradiation, yet only three of the 15 had received previous cranial irradiation. Five of 30 had thyroid d...

criteria and 40% in the best schedule (5-day intravenous). This compares favorably with prior experiences with decitabine and 5-azacitidine (CR rates, 6%-20%).4,5 Also, decitabine was less toxic than 5-azacitidine in relation to nausea/vomiting and local skin reactions (pain and induration in 5%-10% of patients on 5-azacitidine). The incidence of 65% of hospitalization is cumulative. As one del...

Two children developed papillary thyroid carcinoma after allogeneic bone marrow transplantation (BMT) probably due to radiotherapy during remission and pretransplantation conditioning. Establishing a relationship between the cellular thyroid stimulating hormone (TSH) effect and development of carcinoma in cases with high serum TSH concentrations is difficult. After BMT, patients should be regul...

Total body irradiation (TBI) is a well-established component of several conditioning regimens required before bone marrow or hematopoietic stem cell transplantation. In this work, we validate the imparted dose in TBI technique using VMAT Médica Sur. We used an anthropomorphic phantom ATOM 702-D, CIRS (Norfolk, Virginia), add upper extremities homemade material and scanned it CT scanner GE 580RT...

Radiation may affect essential functions and behaviors such as locomotion, feeding, learning and memory. Although whole-body irradiation has been shown to reduce motility in the nematode Caenorhabditis elegans, the detailed mechanism responsible for this effect remains unknown. Targeted irradiation of the nerve ring responsible for sensory integration and information processing would allow us t...

Total-body irradiation (TBI), when given as part of bone marrow transplantation (BMT), works by enhancing immune suppression and by exerting a tumoricidal effect. The modality has been made less toxic because of new approaches to delivering TBI, such as fractionation, and partial organ shielding, Colleen Lawton, MD, professor at the Medical College of Wisconsin, Milwaukee, said at the 1998 Amer...

HERBERT S. SLSE, JACQUES GAUTHIEB, ROBERT BECKER AND JOHN Boz. c n H EMORRHAGE has been an important and ominous sign in victims of irradiation effects. Although its occurrence coincided with a period of intense thrombocytopenia, Allen and Jacobson1 in experimental observations in dogs observed a circulating heparin-like anticoagulant, and Allen2 concluded that it played an important role in th...

Late effects of chemo-radiotherapy conditioning before bone marrow transplantation (BMT) are being increasingly recognised in long-term survivors, particularly children. They can be divided into two categories: those affecting hormonal status and those affecting specific organ function. All women treated develop ovarian failure with low levels of beta-oestradiol and raised values of follicle-st...

first was a staphylococcus albus infection which arose in a primary ventriculoatrial shunt inserted in a 60-year-old patient who had developed hydrocephalus in association with a cystic tumour of the posterior fossa. The second was an Escherichia coli infection which occurred after a revision of the upper end of a ventriculoperitoneal shunt in a 2-year-old child who had hydrocephalus caused by ...