1 Introduction Plastocyanin (PC) is a small (M r 10 500), 'blue' copper protein which transfers electrons from cyto-chrome / to the primary electron donor of photosystem I (P700) in the photosynthetic electron transport chain. It reacts rapidly with cytochrome / in vitro and also with several other cytochromes, although somewhat more slowly [1].. The crystal structures of both oxidized and redu...

Tyramine β-monooxygenase (TβM) belongs to a family of physiologically important dinuclear copper monooxygenases that function with a solvent-exposed active site. To accomplish each enzymatic turnover, an electron transfer (ET) must occur between two solvent-separated copper centers. In wild-type TβM, this event is too fast to be rate limiting. However, we have recently shown [Osborne, R. L.; et...

Blue copper proteins are categorized into three types (type1, type2, and type3) by their structures and functions. Azurin is one of the type 1 blue copper protein. The structure consists of eight β strands and an α helix with 128 residues. Azurin has the functionality of electron transfer because of their prominent reactivity. The active site of azurin consists of a copper ion and five ligand r...

Recent investigations tend heavily to support the view that ascorbic acid oxidase is a specific enzyme containing copper as the prosthetic group of a blue-green conjugated protein having a molecular weight of about 150,000 (1, 2). Little is known at the present time concerning either the nature of the copper-protein bond in the enzyme or the function of the enzyme copper in the catalytic proces...

HE BIURET REACTION has become an important analytic procedure for rapid and accurate determinations of protein concentrations in biologic fluids. Since the initial reports of Riegler (1), Autenrieth and Mink (2), and Autenrieth (3), who showed that proteins react with alkaline copper solutions to yield a violet-blue color, many modifications have appeared to improve the stability of alkaline co...

this study was conducted to investigate effect of different sources of copper on gas production parameters and nutrients digestibility in zandi male lambs. in the first experiment, 18 male lambs (initial body weight 17.53±1.62) divided into three groups and fed one of the three experimental diets for 70 days. dietary treatments were control (basal diet without copper supplement), basal diet plu...

Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease, with no effective pharmacological treatment. Its pathogenesis is unknown, although a subset of the cases is linked to genetic mutations. A significant fraction of the mutations occur in one protein, copper, zinc superoxide dismutase (SOD1). The toxic function of mutant SOD1 has not been elucidated, but damage to the meta...