Thyroid hormones are key players in regulating brain development. Thus, transfer of appropriate quantities of thyroid hormones from the blood into the brain at specific stages of development is critical. The choroid plexus forms the blood-cerebrospinal fluid barrier. In reptiles, birds and mammals, the main protein synthesized and secreted by the choroid plexus is a thyroid hormone distributor ...

Steroid sex hormones play a central role in breast carcinogenesis. Evidence from in vitro and animal studies suggests that phytoestrogens may inhibit the development of mammary tumors through their role in regulating the synthesis, metabolism, and signal transduction of steroid hormones. In a study of 117 case-control pairs of postmenopausal women in Shanghai, we investigated whether the associ...

background: considering the controversial information regarding the effects of perchlorate on thyroid function of high risk population as neonates, and given the high prevalence rate of thyroid disorders specially congenital hypothyroidism in our region, this study aims to investigate for the frst time in iran, the relationship between drinking groundwater perchlorate and cord blood thyroid hor...

The juvenile hormones (JH) in extracts of Manduca sexta blood were converted to 10-(2,4-dichlorobenzoyloxy)-11-methoxy derivatives and quantitatively determined by gas chromatography with electron capture detection. Early IVth instar larvae contained 0.62 ng JH-I, 1.1ng JH-II and 0.07 ng JH-III per ml blood. Early Vth instar larvae, and adult of both sexes contained the hormones in concentratio...

Introduction Blood sugar homeostasis relies largely on the action of pancreatic islet hormones, particularly insulin and glucagon. In a prototypical fashion, glucagon is released upon hypoglycemia to elevate glucose by acting liver while elevated induces secretion which leads uptake peripheral tissues. This simplified view does not consider paracrine roles two hormones modulating response α- β-...

Background and Aims: 25-hydroxy vitamin D3 is recognized to be an essential element for healthy body; however, its deficiency has been identified as a risk factor for thyroid disease, diabetes mellitus and other autoimmune diseases and infectious diseases. Thyroid disease is common in the general population that its prevalence increases proportional to age. Subjects with poorly controlled diabe...