A hemoglobin (Hb) wrapped covalently by human serum albumins (HSAs), a core-shell structured hemoglobin-albumin cluster designated as "HemoAct", is an O2-carrier designed for use as a red blood cell (RBC) substitute. This report describes the blood compatibility, hemodynamic response, and pharmacokinetic properties of HemoAct, and then explains its preclinical safety. Viscosity and blood cell c...

There are a multitude of polymeric materials currently utilized to prepare a variety of blood-contacting implantable medical devices. These devices include tissue grafts, coronary artery and vascular stents, and orthopedic implants. The thrombogenic nature of such materials can cause serious complications in patients, and ultimately lead to functional failure. To date, there is no truly hemocom...

Recent improvements in the antithrombogenic properties of blood contacting biomaterials permit a hybrid design of layers for biomedical applications such as artificial heart valves and stents. Using magnetron sputtering and thermal oxidation, titanium oxide thin films containing tantalum. Ti(Ta(+5))O2, are fabricated to meet the challenge of enhanced hemocompatibility. The blood compatibility i...

A novel kind of functional sutures was developed by combining electrospinning with a braiding technique. After post treatments, the electrospun PLLA nanofiber threads which were collected uniaxially were made into a more compact braided wire. Chitosan was used as a coating agent to make the braided wire surface smoothened and functionalized. Morphology and mechanical properties of the PLLA sutu...

Magnesium (Mg) alloy has been used for medical vascular stents because of its good biocompatibility and degradability, but rapid degradation poor blood compatibility limits further application. In this study, ferulic acid (FA) was conjugated onto the polydopamine (PDA) deposited Mg-Zn-Y-Nd to prepare a PDA/FA multi-functional coating with better corrosion resistance compatibility. The results s...

determination of blood compatibility is an important problem in blood contacting devices. in this study, two classes of materials including polyurethane (based on polyethylene glycol and poly tetrametylene oxide) and polyvinyl alcohol samples, with different hydrophilicity properties were synthesized and their physico-chemical properties were compared. water uptake ratio, ftir spectroscopy, and...

In the past two decades many attempts have been made t o relate surface and interfacial parameters with the blood compatibility of polymeric surfaces. It is however doubtful if by a single parameter the behaviour of blood on a surface can be predicted. Two major aspects of blood compatibility -the prevention of platelet adhesion and the deactivation of the intrinsic coagulation system are deter...