Currently, anti-PD-1/PD-L1 immunotherapy using immune checkpoint inhibitors is widely used in the treatment of multiple cancer types including lung cancer, which a leading cause death world. However, only limited proportion patients will benefit from therapy. Therefore, it importance to predict response for precision patients. Although expression PD-L1 and tumor mutation burden (TMB) are common...

Background: Colorectal cancer is a common cancer and has a high rate of mortality and morbidity. This can be reduced by screening tests. Some of the studies have recently referred to Red Cell Distribution Width (RDW) as a marker for early detection of various cancers. The aim of this study was to investigate the RDW and early detection of colorectal cancer and polyp. M...

angiogenesis which is the recruitment of new blood vessels is a critical process in several chronic diseases and is an essential component of tumor or cancer progression. development of therapies aimed at inhibiting the angiogenesis, in combination with classical anti-cancer therapies, is among the most intensively studied approaches to treat the cancer. in this study the effect of chlordiazepo...

For optimal pancreatic cancer treatment, early and accurate diagnosis is vital. Blood-derived biomarkers genetic predispositions can contribute to diagnosis, but they often have limited accuracy or applicability. Here, we seek exploit the synergy between them by combining biomarker CA19-9 with RNA-based variants. We use deep sequencing learning improve differentiating chronic pancreatitis. obta...

Endocan expression has been associated with aggressive tumor progression and poor outcomes in various cancers. Our preclinical study demonstrated that endocan the peripheral blood potential for use as a prognostic biomarker of triple-negative breast cancer （TNBC）. Currently, clinical results collected from patients are extremely limited. Thus, this aimed to examine extent which correlates stagi...

Background: Full blood count has been shown to predict disease severity and mortality risk in cancer patients. This study aimed to highlight the degree of derangements of full blood count parameters and provide mean values in pre-chemotherapy breast cancer patients compared with apparently normal control subjects.Methods: This was an unmatched case-control study among breast cancer patients att...

background: ovarian cancer is the fifth leading cause of death from malignancy in women. cd4 +cd25+foxp3+ regulatory t (treg) cells are a subset of t lymphocytes with great inhibitory impact on immune response. objectives: to investigate the percentage of cd4 +cd25+foxp3+ regulatory t cells in the peripheral blood of the iranian patients with epithelial ovarian cancer compared to healthy women ...

Background: Interleukin (IL)-23 and IL-27 are two IL-12-related cytokines which their function may dramatically influence the inflammatory response to tumor development. IL-12 and IL-27 seem to have antagonistic roles with IL-23 in tumor site. In this study, IL-23 and IL-27 mRNA expressions were analyzed in peripheral blood of patients with breast cancer and healthy volunteers using quantitativ...