Epidermolysis bullosa (EB) encompasses a heterogeneous group of genodermatoses, characterized by fragility and blistering of the skin, often associated with extracutaneous manifestations. The level of vesiculation within the skin defines 3 major subtypes of EB: EB simplex, junctional EB, and dystrophic EB. We present the case of a male neonate of 36 weeks of gestation, who was born with a few b...

Disease summary: Bullous Pemphigoid is an acquired, chronic, blistering autoimmune subepidermal bullous disease in which autoantibodies are directed against component of basement membrane zone of the skin [1]. It is characterized by formation of cutaneous bullae on the skin and mucous membrane. The pathogenesis involves migration of inflammatory cells into subepithilial tissues due to activatio...

Pemphigoid diseases are a group of well defined autoimmune disorders. The most common of these diseases is bullous pemphigoid, which. Abstract Bullous pemphigoid BP is a blistering skin disease. Plex and includes bullous pemphigoid, pemphigoid gestationis, mucous.Bullous pemphigoid BP is an autoimmune subepidermal bullous dermatosis defined. Http:www.orpha.netdatapathoGBukBullousPemphigoid.pdf....

Bullous pemphigoid (BP) is an autoimmune blistering skin disease, of which the incidence has increased in recent years. BP characterized by circulating IgG and IgE autoantibodies against hemidesmosomal proteins BP180 BP230. Although trigger inflammatory cascades that lead to blister formation, effector cells cell-mediated autoimmunity must also be considered as important factors pathogenesis BP...

Pemphigus foliaceus is a benign variety of pemphigus group. It rare autoimmune blistering disease that affects the skin without mucosal involvement. can present in endemic and sporadic form; whereby form common Brazil Tunisia, known as fogo selvagem. There was no previous case reported Malaysia. We report 43-year-old man, who presented with generalized extensive blisters vesicles crust scale. T...

The cross-linking of the IgA Fc receptor (FcαRI) by IgA induces release of the chemoattractant LTB4, thereby recruiting neutrophils in a positive feedback loop. IgA autoantibodies of patients with autoimmune blistering skin diseases therefore induce massive recruitment of neutrophils, resulting in severe tissue damage. To interfere with neutrophil mobilization and reduce disease morbidity, we d...

Deficient epidermal adhesion is a hallmark of blistering skin disorders and chronic wounds, implicating integrins as potential therapeutic targets. Integrin α3β1, a major receptor in the epidermis for adhesion to laminin-332 (LN-332), has critical roles in basement membrane (BM) organization during skin development. In the current study we identify a role for α3β1 in promoting stability of nasc...

Susceptibility to chronic inflammatory diseases is determined by immunogenetic and environmental risk factors. Resident microbial communities often differ between healthy and diseased states, but whether these differences are of primary aetiological importance or secondary to the altered inflammatory environment remains largely unknown. Here we provide evidence for host gene-microbiota interact...