A 58-yr-old male patient presented in the be differentiated by the presence of the blastic phase of chronic myelogenous IeuPh’ chromosome and the stigmata of CML. kemia (CML) . Cytogenetic studies revealed Absence of the Y chromosome from the a 45 XO Ph’ chromosome pattern in bone bone marrow in CML is a recently demarrow cells during a short remission and scribed finding. Previous reports indi...

The expression of a cell cycle-related nucleolar protein (p145) antigen was examined in the bone marrow aspirates of 45 individuals, three of whom had no malignant disease; 30 had a diagnosis of acute myeloid leukemia (AML), and 12 suffered from chronic myeloid leukemia (CML). While no evidence of p145 expression was found in the three normal bone marrow samples, it was noted to be the highest ...

I T IS WELL KNOWN that the blastic cells in acute leukemia often show numerical or other aberrations from the normal karyotype, which permit their characterization as stem lines.13 While these may undergo further evolution, they generally remain identifiable during consecutive relapses throughout the course of the disease,4’5 thus constituting evidence for the persistence of an autonomous cell ...

1. Lawson DM, Murray RM, Parker JLW: Early mortality in the megaloblastic anaemias. QJ Med4l:l, 1972 2. FisheniR: Hypokalemia in acute lymphoblastic leukemia. Ann Intern Med 86:363, 1977 3. Yseung K, Trowbnidge AA: Chronic granulocytic leukemia: Hypokalemia in acute blastic crisis. Ann Intern Med 85:533, 1976 4. Holland MR. Jacobs AG, Kitis G: Pseudohyperkalemia in acute lymphocytic leukemia. L...

I N CHRONIC GRANULOCYTIC LEUKEMIA neurologic manifestations due to leukemic infiltration of the central nervous system occur uncommonly.’ In acute lymphoblastic leukemia, on the other hand, diffuse leukemic infiltration of the lepto-meninges is frequent and must be differentiated from neurologic involvement due to infection, hemorrhage, or drug toxicity.2 \Vhen acute myeloblastic transformation...

Forty-six patients with chronic myeloid leukemia receiving imatinib mesylate (39 in chronic phase, one in accelerated phase, and six in blastic crisis), were studied for a 20-62 month follow-up period by cytogenetics and fluorescence in situ hybridization using dual-color, dual-fusion BCR and ABL probes. This approach provided valuable results for disease management of analysis.

We present a case of plasmacytoid lymphocytic leukemia with hairy-cell-like cytoplasmic projections and separate monomeric and polymeric IgA(lambda) serum bands confirmed by immunofixation. After a prolonged initial good response to chemotherapy, the patient had recurrent disease with increased plasmacytoid blastic feature and died. The relationship of this case to B-cell proliferative disorder...

In a patient with juvenile myelomonocytic leukemia, a NRAS mutation at codon 12 (GGT>TGT) was initially heterozygous, but became homozygous after blastic crisis (BC). According to microsatellite and FISH analyses, the post-BC homozygous mutation might result from the loss of the wild-type NRAS locus through mitotic recombination.

The expression of a cell cycle-related nucleolar protein (pl4S) antigen was examined in the bone marrow aspirates of 45 individuals, three of whom had no malignant disease; 30 had a diagnosis of acute involimi leukemia (AMI), and 12 suffered from chronic myeloid leukemia (CML). While no evidence of pl45 expression was found in the three normal bone marrow samples, it was noted to be the highest...