OBJECTIVE To identify genetic and nongenetic factors contributing to the risk of bladder exstrophy-epispadias complex (BEEC). PATIENTS AND METHODS In all, 285 families with BEEC were invited to participate in the study, and 232 of them were recruited. Epidemiological information was obtained from 151 of the consenting families, with a detailed clinical genetic examination of 94 probands. In a...

The role of the pelvic osteotomy at the time of bladder exstrophy closure has been better defined over the past three decades. Modern radiographic imaging provides greater insight into the pelvic bony and muscular defects encountered with these children and has forced surgeons to reconsider the importance of reconstructive efforts beyond the genitourinary tract. Surgical series from several of ...

BACKGROUND Bladder exstrophy occurs in approximately 1 in 35,000 live births and is associated with an increased incidence of bladder cancer. CASE PRESENTATION A 55-year old male patient was diagnosed with a primary mucinous adenocarcinoma of an unreconstructed exstrophic bladder. Examination of the entire gastrointestinal tract shown there were not other primary cites. Immunohistochemistry c...

Objective: Physiological outcomes in patients of cloacal exstrophy are governed primarily by neurological innervation and detrusor histomorphology. An evaluation of the bladder plate histomorphology for the presence of neural elements, collagen fibres and smooth muscle components was done and correlation attempted with detrusor physiology. Methods: From three cases of cloacal exstrophy, full th...

This is to report the case of a huge vaginal stone, and bladder calculi in a 26-year-old woman with previous operation of bladder exstrophy. It seems that the vaginal stone was secondary to the remaining wire used in her previous reconstructive surgery for pelvic closure 20 years ago and now surgery is performed to remove the vaginal and bladder stones.

Materials and Methods: 133 Mitrofanoff channels (100 appendicular, 31 ureteric and 2 Monti) were constructed in 122 children (93 boys and 29 girls) of mean age 6.3 years over the period from 1997 to 2005. The procedure was part of the reconstructive procedure in patients of neurogenic bladder (n=44), exstrophy-epispadias (n=40), posterior Urethral valve (n=30), and other diseases (n=8). Additio...