The purpose of this study was to evaluate the accuracy of commercially available software, using patient DVH-based QA metrics, by investigating the correlation between estimated 3D patient dose and magnitude of MLC misalignments. We tested 3DVH software with an ArcCHECK. Two different calculating modes of ArcCHECK Planned Dose Perturbation (ACPDP) were used: "Normal Sensitivity" and "High Sensi...

The focus of this work is the dosimetric impact of multileaf collimator (MLC) leaf width on the treatment of prostate cancer with intensity-modulated radiation therapy (IMRT). Ten patients with prostate cancer were planned for IMRT delivery using two different MLC leaf widths--4mm and 10mm--representing the Radionics micro-multileaf collimator (mMLC) and Siemens MLC, respectively. Treatment pla...

Purpose This study is intended to compare dose-volume parameters evaluated using different forward planning- optimization techniques, involving two applicator systems in intracavitary brachytherapy for cervical cancer. It looks for the best applicator-optimization combination to fulfill recommended dose-volume objectives in different high-dose-rate (HDR) fractionation schedules. Material and ...

PURPOSE To compare the quality of 5-channel vaginal cylinder treatment plans for endometrial cancer to single channel and 9-channel plans. Using more channels tends to spare the rectum and bladder, while creating hot spots and longer planning and treatment times. The objective is to determine if the 5-channel plans offer a beneficial compromise to the single and 9-channel plans. METHODS Fifte...

The aim of this study was to investigate the potential of jaw tracking with the volumetric-modulated arc therapy (VMAT) to reduce the normal tissue dose. Plans of nasopharynx, lung, and prostate cancers (10 plans for each) were used to perform VMAT with and without jaw tracking. The dose reduction was evaluated in terms of organ doses and integral doses. Organ-dose reduction with jaw tracking w...

BACKGROUND Comparing radiation treatment plans to ascertain the optimal intensity-modulated radiation technique for low-risk prostate cancer. METHODS Treatment plans for 20 randomly selected patients were generated using the same dose objectives. A dosimetric comparison was performed between various intensity-modulated techniques, including protons. All treatment plans provided conventional t...

BACKGROUND To establish a generalized equivalent uniform dose (gEUD) -based prescription method for Image Guided Brachytherapy (IGBT) that reproduces the Gyn GEC-ESTRO WG (GGE) prescription for cervix carcinoma patients on CT images with limited soft tissue resolution. METHODS The equivalence of two IGBT planning approaches was investigated in 20 patients who received external beam radiothera...

PURPOSE To retrospectively compare the potential dosimetric advantages of a multichannel vaginal applicator vs. a single channel one in intracavitary vaginal high-dose-rate (HDR) brachytherapy after hysterectomy, and evaluate the dosimetric advantage of fractional re-planning. MATERIAL AND METHODS We randomly selected 12 patients with endometrial carcinoma, who received adjuvant vaginal cuff ...

PURPOSE To develop and evaluate the clinical applicability of advanced machine learning models that simultaneously predict multiple optimization objective function weights from patient geometry for intensity-modulated radiation therapy of prostate cancer. METHODS A previously developed inverse optimization method was applied retrospectively to determine optimal objective function weights for ...