PURPOSE The purpose of this study was to evaluate bone response to anodized titanium implants coated with the extract of black cohosh, Asarum Sieboldii, and pharbitis semen. MATERIALS AND METHODS FORTY ANODIZED TITANIUM IMPLANTS WERE PREPARED AS FOLLOWS: group 1 was for control; group 2 were implants soaked in a solution containing triterpenoids extracted from black cohosh for 24 hours; group...

PURPOSE Most breast cancer survivors experience hot flashes; many use complementary or alternative remedies for these symptoms. We undertook a randomized clinical trial of black cohosh, a widely used herbal remedy for menopausal symptoms, among breast cancer patients. PATIENTS AND METHODS Patients diagnosed with breast cancer who had completed their primary treatment were randomly assigned to...

OBJECTIVE The aim of this study was to determine the effects of the isopropanolic extract of black cohosh (Remifemin) on mammographic breast density and breast epithelial proliferation in healthy, naturally postmenopausal women with climacteric symptoms. DESIGN This was a prospective, open, uncontrolled drug safety study in which baseline status was compared with status after 6 months of trea...

BACKGROUND This study aims to evaluate the efficacy of Black cohosh (Cimicifuga racemosa L.) in treating early menopausal symptoms. METHODS This randomized, double-blind, placebo-controlled clinical trial was conducted on 84 early post-menopausal participants with Greene climacteric scale (GCS) scores of 15 to 42, who were referred to two public health care centers in Tehran, Iran, in 2011-20...

METHODS: This randomized, multicenter, double-blind clinical trial compared the efficacy and tolerability of the isopropanolic black cohosh extract in the treatment of climacteric complaints compared with placebo. A total of 304 patients were randomly allocated to receive tablets corresponding to 40mg drug ormatching placebo daily for 12 weeks. The primary efficacy measure was the change from b...

Herbal medicines have been used for the treatment of various ailments since time immemorial. Black cohosh (BC) is well known for the treatment of postmenopausal symptoms, with conflicting evidence supporting its safety and benefits. We present a rare case of BC-induced autoimmune hepatitis (AIH) with hepatotoxicity in a 69-year-old female. To our knowledge, this represents the third case of BC-...

Joseph M. Betz, PhD Linda Anderson, PhD Mark I. Avigan, MD Joanne Barnes, PhD Norman R. Farnsworth, PhD Barbro Gerdén, MD Leigh Henderson, MS Edward J. Kennelly, PhD Uwe Koetter, PhD Stephanie Lessard, MS Tieraona Low Dog, MD, PhD Michelle McLaughlin, BS Belal Naser, MD Ruediger G. W. Osmers, MD, PhD Linda S. Pellicore, PhD John R. Senior, PhD Richard B. van Breemen, PhD Wolfgang Wuttke, MD Joh...

Recently, the European Medicines Agency (EMEA) and the Committee on Herbal Medicinal Products (HMPC) have released a public statement to draw the attention of European health authorities to 42 cases (34 directly reported from European national competent authorities and 8 published) of suspected hepatotoxic reactions to Cimicifugae racemosae rhizoma (black cohosh, root) in patients, probably all...