نتایج جستجو برای: bkv subtypesubgroup

تعداد نتایج: 379  

Journal: :Journal of clinical microbiology 2011
A Dumoulin H H Hirsch

PCR-based molecular assays have a central role in polyomavirus diagnostics. To assure optimal performance, target sequences should be regularly updated according to newly available sequences. The aim of this study was to review our in-house polyomavirus BK (BKV) and JC (JCV) real-time PCR assays. Database analysis revealed variations in the BKV target region which might affect the assay perform...

Journal: :Journal of virology 1979
C J Lai N D Goldman G Khoury

The functional properties of the early antigens of simian virus 40 (SV40) and human papovavirus BK (BKV) were investigated. Infection of African green monkey kidney cells with BKV permitted the bidirectional replication of an early temperature-sensitive mutant (tsA) at a nonpermissive temperature. Conceivably, an early gene product (T-antigen) of BKV can substitute functionally for the defectiv...

Journal: :Journal of virology 2009
Mengxi Jiang Johanna R Abend Billy Tsai Michael J Imperiale

BK virus (BKV) is a nonenveloped, ubiquitous human polyomavirus that establishes a persistent infection in healthy individuals. It can be reactivated, however, in immunosuppressed patients and cause severe diseases, including polyomavirus nephropathy. The entry and disassembly mechanisms of BKV are not well defined. In this report, we characterized several early events during BKV infection in p...

2012
Valerie Neirynck Kathleen Claes Maarten Naesens Liesbeth De Wever Jacques Pirenne Dirk Kuypers Yves Vanrenterghem Hendrik Van Poppel Andre Kabanda Evelyne Lerut

BK virus (BKV) is known to cause subclinical infection in childhood. The virus remains latent in the human body, mainly in the urinary tract epithelium. After initiation of an immunosuppressive treatment, reactivation can occur in renal transplant recipients. BKV can cause hemorrhagic cystitis, ureteral stenosis and BKV nephropathy in immunocompromised patients. Furthermore, a number of case re...

Journal: :The new microbiologica 2007
Monica Mischitelli Daniela Fioriti Elena Anzivino Anna Bellizzi Giancarlo Ferretti Norberto Gussman Anna Paola Mitterhofer Francesca Tinti Mario Barile Maurizio Dal Maso Fernanda Chiarini Valeria Pietropaolo

BKV associated nephropathy (BKVAN) is a cause of renal dysfunction and loss of the graft in transplants. Viral primary infection is usually inapparent and then BKV establishes latency in kidneys. Reactivation occurs in immunocompromised conditions in renal transplant recipients who can develop a subclinical nephritis and eventually a BKV-associated interstitial nephritis or a BKVAN. In this stu...

Journal: :Journal of clinical microbiology 2009
Sohrab Bodaghi Patrizia Comoli Robert Bösch Alberta Azzi Rainer Gosert David Leuenberger Fabrizio Ginevri Hans H Hirsch

BK virus (BKV)-specific immunity is critical for polyomavirus-associated nephropathy, but antibody responses are incompletely defined. We compared the hemagglutination inhibition assay (HIA) with immunoglobulin G enzyme immunoassays (EIA) to BKV proteins expressed in baculovirus-infected insect cells. N-terminal, internal, and C-terminal domains of the BKV large T antigen (BKLT) were fused to g...

Journal: :Journal of clinical microbiology 2015
Malaya K Sahoo Susanna K Tan Sharon F Chen Beatrix Kapusinszky Katherine R Concepcion Lynn Kjelson Kalyan Mallempati Heidi M Farina Marcelo Fernández-Viña Dolly Tyan Paul C Grimm Matthew W Anderson Waldo Concepcion Benjamin A Pinsky

BK virus (BKV) infection causing end-organ disease remains a formidable challenge to the hematopoietic cell transplant (HCT) and kidney transplant fields. As BKV-specific treatments are limited, immunologic-based therapies may be a promising and novel therapeutic option for transplant recipients with persistent BKV infection. Here, we describe a whole-genome, deep-sequencing methodology and bio...

2011
Mona Johannessen Mari Walquist Nancy Gerits Marte Dragset Anne Spang Ugo Moens

BACKGROUND The human polyomavirus BK (BKV) infects humans worldwide and establishes a persistent infection in the kidney. The BK virus genome encodes three regulatory proteins, large and small tumor-antigen and the agnoprotein, as well as the capsid proteins VP1 to VP3. Agnoprotein is conserved among BKV, JC virus (JCV) and SV40, and agnoprotein-deficient mutants reveal reduced viral propagatio...

Background: Primary infection with BK virus (BKV) is occurred during childhood and usually asymptomatic, but after initial infection, BKV may persist lifelong in the kidney and genitourinary tract. Reactivation may occur in individuals with compromised immunity such as renal transplant recipients. Due to the role of BKV in BK virus-associated nephropathy (BKVAN) and po...

Journal: :Acta medica Okayama 1983
M Tsuboi

The localization of both the large T and small t tumor (T) antigens in cultured cells (Vn 12 cells) of hamster brain tumors induced with BK virus (BKV), a new human papovavirus, was studied by an enzyme labelled antibody method at both the light and electron microscopic levels. Under the light microscope, BKV T antigen was observed in the nucleus, except for the nucleoli, of cells in interphase...

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