OBJECTIVE To summarize the literature concerning the use of bisphosphonates in the prevention and treatment of corticosteroid-induced osteoporosis and make recommendations concerning the proper use of these agents. SEARCH STRATEGIES We conducted a literature search to identify studies in the English language concerning the use of bisphosphonates in the prevention or treatment of corticosteroi...

A variety of human cancers, including nonsmall cell lung (NSCLC), breast, and colon cancers, are driven by the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases. Having shown that bisphosphonates, a class of drugs used widely for the therapy of osteoporosis and metastatic bone disease, reduce cancer cell viability by targeting HER1, we explored their potential uti...

BACKGROUND/AIMS To highlight the potential ocular side effects of bisphosphonate therapy and the importance of a proper drug history in patients who present with uveitis. METHODS We report 2 cases of bilateral uveitis secondary to bisphosphonate therapy. Both patients were on nitrogen-containing bisphosphonates when they developed symptoms of bilateral anterior uveitis. A uveitis screen done ...

Abstract Bisphosphonates remain the most used and effective drugs for treatment of systemic bone diseases followed by resorption. Although their side effects in a form alveolar osteonecrosis have been reported, bisphosphonates potential being common oral resorption such as peri-implantitis, periapical lesions, periodontitis. The aim this article was to review recent research regarding use field...

Bisphosphonates are widely used for the prevention and treatment of osteoporosis in adulthood. In the last years, bisphosphonates have been increasingly used in pediatric patients for the treatment of a growing number of disorders associated with osteoporosis, resistant hypercalcemia or heterotopic calcifications. The use of bisphosphonates in pediatric patients has been proven safe; however, t...

Bisphosphonates are highly effective in preserving bone mineral density and have a favorable benefi t-risk profi le. Thereby, bisphosphonates became the preferred antiresorptive drug for malignant and nonmalignant diseases characterized by various kinds of bone loss. In general, bisphosphonates may be considered as treatment option for preserving bone mineral density in any disease accompanied ...

BACKGROUND Bisphosphonates have exhibited anti-tumor activity in non-small cell lung cancer (NSCLC). We aimed to evaluate whether the combination of bisphosphonates with tyrosine kinase inhibitors of EGFR (EGFR-TKIs) could obtain a synergistic effect on advanced NSCLC patients with EGFR mutations. METHODS Between January 2008 and October 2013, 114 advanced EGFR mutations NSCLC patients who re...

Bisphosphonates have an established role in treating tumor-induced hypercalcemia and decreasing the incidence of skeletal-related events. Recent data suggest that these agents may also prevent skeletal metastases. This review explains how cancer metastasizes to bone and how bisphosphonates may block this process, with a summary of clinical trials supporting the use of bisphosphonates to treat a...