An investigation into the biopharmaceutics classification and a study of the in vitro bioavailability (permeability and solubility) of the antiviral compound enisamium iodide (4-(benzylcarbamoyl)-1-methylpyridinium iodide) were carried out. The solubility of enisamium iodide was determined in four different buffers. Apparent intestinal permeability (Papp) of enisamium iodide was assessed using ...

IV. Láng, P.; Kiss, V.; Ambrus, R.; Farkas, G.; Szabó-Révész, P.; Aigner, Z.; Várkonyi, E., Screening of polymorph forms of a former drug candidate: 8 th Word Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Istanbul, Turkey, 19-22. March 2012., Solid State Characterisation /P184/ V. Láng, P.; Kiss, V.; Szabó-Révész, P.; Aigner, Z., Várkonyi, E., Potenciális farmakonjel...

ChemGPS, the chemical global positioning system, is a tool that combines rules (equivalent to dimensions) and objects (chemical structures) to provide a consistent chemical space map (Oprea, T. I.; Gottfries, J. J. Comb. Chem. 2001, 3, 157-166.). Rules included, initially, general properties such as size, lipophilicity, and hydrogen bond capacity, while objects include "satellites", intentional...

L. VLASE, M. PARVU, E. A. PARVU, A. TOIU Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, 12 Ion Creanga Street, 400010 Cluj-Napoca, Romania b Department of Biology, Faculty of Biology and Geology, „Babes-Bolyai” University, 42 Republicii Street, 400015 Cluj-Napoca, Romania c Department of Pathophysiology, ...

The biopharmaceutics classification system (BCS) and biopharmaceutics drug distribution classification system (BDDCS) are complementary classification systems that can improve, simplify, and accelerate drug discovery, development, and regulatory processes. Drug permeability has been widely accepted as a screening tool for determining intestinal absorption via the BCS during the drug development...

I. Szűcs Mária: Polimer emulgensekkel stabilizált emulziók, Ph.D. Tudományos Nap, Szegedi Akadémiai Bizottság Székháza, 2006. május 3. II. István Erős, Mária Szűcs, Szabolcs Budai, Erzsébet Csányi, Zsolt Makai, Péter Sipos, András Fehér and Piroska Szabó-Révész: Physico-chemical investigation of acrylate based polymeric emulsifiers, 5th World Meeting on Pharmaceutics Biopharmaceutics and Pharma...

Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192 (T. N., Y. S., Y. F., H. F., Y. S., I. T.) and Department of Membrane Transport and Pharmacokinetics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamasaki, Noda, Chiba 278-8510 (Y. S.,...

Authors: Daisuke Kobayashi, Takashi Nozawa, Kozue Imai, Jun-ichi Nezu, Akira Tsuji and Ikumi Tamai Department of Molecular Biopharmaceutics, Faculty of Pharmaceutical Sciences, Tokyo University of Sciences (D.K., T.N., K.I., I.T.), Tokyo, Japan; Department of Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, Kanazawa University (D.K., T.N., A.T.), Kanazawa, Japan; Core Research for Ev...

Several biologically relevant phospholipids were assessed as potential carriers/additives for rapidly dissolving solid formulations of piroxicam (Biopharmaceutics Classification System Class II drug). On the basis of in vitro dissolution studies, dimyristoylphosphatidylglycerol (DMPG) was ranked as the first potent dissolution rate enhancer for the model drug. Subsequently, the solid dispersion...

Genki Minegishia, Yasuhiro Kazukibc, Shin-Ichiro Nittad, Atsushi Miyajimae, Hidetaka Akitaa & Kaoru Kobayashie*a Laboratory of DDS Design and Drug Disposition, Graduate School Pharmaceutical Sciences, Chiba University, Chiba, Japanb Chromosome Engineering Research Center (CERC), Tottori Tottori, Japanc Department Molecular Cellular Biology, Division Genome Functions, Faculty Medicine, Life Scie...