OBJECTIVE To evaluate the compatibility of novel nano-calcium-deficient hydroxyapatite/poly-amino acid (n-CDHA/PAA) complex biomaterials with muscle and bone tissue in an in vivo model. METHODS Thirty-two New Zealand white rabbits were used in this study. Biomaterials were surgically implanted into each rabbit in the back erector spinae and in tibia with induced defect. Polyethylene was impla...

statement of problem: dental resin composites are becoming prevalent in restorative dentistry and have almost replaced amalgam nowadays. consequently, their mechanical properties and durability are critical. objectives: the aim of this study was to produce pyrex glass nano-particles by wet milling process and use them as reinforcement in dental resins for anterior restorations and then examinat...

Tissue-engineered biomaterials have existed approximately 40 years as simple biomimetic structures. Replacement of human tissue with new tissue can be accomplished by generating replacements outside of the body or in situ in the body. In each case, the key elements are described as the tissue engineering triad of scaffolds, cells, and signals. Scaffolds can be produced synthetically or derived ...

Biocompatible materials used for the fabrication of dental crowns were studied. Patients were treated with Gold, Porcelain and Zirconia crowns. Dental crowns were selected according to patient’s clinical status and needs. We found that Gold crowns had low patient acceptance because of poor aesthetics and high cost. Gold crowns could not be used opposite to amalgam restorations for the fear of g...

Terpenoids (isoprenoids) encompass more than 40 000 structures and form the largest class of all known plant metabolites. Some terpenoids have well-characterized physiological functions that are common to most plant species. In addition, many of the structurally diverse plant terpenoids may function in taxonomically more discrete, specialized interactions with other organisms. Historically, spe...

Biotherapy mainly refers to the intervention and the treatment of major diseases with biotechnologies or bio-drugs, which include gene therapy, immunotherapy (vaccines and antibodies), bone marrow transplantation and stem-cell therapy. In recent years, numerous biomaterials have emerged and were utilized in the field of biotherapy due to their biocompatibility and biodegradability. Generally, b...

X-ray microanalysis is commonly applied in biomaterials research to study changes in biomaterial composition, calcifications, or to identify particulates in tissue that has been in contact with biomaterials. Studies where the effect of biomaterials on the naturally occurring elements in the cells are studied are rare. Exposure to or contact with biomaterials may give rise to several cellular re...

Interface tissue engineering (ITE) is a rapidly developing field that aims to fabricate biological tissue alternates with the goal of repairing or regenerating the functions of diseased or damaged zones at the interface of different tissue types (also called "interface tissues"). Notable examples of the interface tissues in the human body include ligament-to-bone, tendon-to-bone and cartilage-t...

Three-dimensional printing has significant potential as a fabrication method in creating scaffolds for tissue engineering. The applications of 3D printing in the field of regenerative medicine and tissue engineering are limited by the variety of biomaterials that can be used in this technology. Many researchers have developed novel biomaterials and compositions to enable their use in 3D printin...

This interdisciplinary program will train the next generation of predoctoral students in the inter-disciplinary field of Biomaterials to rationally design new materials capable of integrating into the body or remodeling in vivo. Two new graduate students each year will be offered the opportunity to participate in a comprehensive training program that includes two semester long rotations – one w...