Molecular epidemiology refers to the incorporation of molecular techniques in epidemiological studies. There are different biomarkers in cancer research used for molecular epidemiology including markers of exposure, markers of dose, susceptibility, treatment response, prognosis, altered structure/function and cancer type. Selected markers, especially those of exposure and susceptibility, are de...

Identification of molecular biomarkers is a common result of current cancer epidemiological research. Both genetic and molecular epidemiology have enjoyed impressive developments in recent decades, with important repercussions on traditional epidemiological approaches. In this paper we evaluate the new frontiers of cancer epidemiology, incorporating both genetic and molecular biology approaches...

For almost twenty years now, huge advances in the field of molecular biology have made it possible to identify molecules or molecular markers that represent the signature of a serious pathology, I mean cancer in particular. Thus, rapid detection enables to envisage first-line treatments such as surgical ablation, for example, which would avoid treatment that is heavier and more invasive for the...

Several DNA molecular markers are now available for use in surveillance and investigation of foodborne outbreaks that were previously difficult to detect. The results from several sources of literature indicate substantially different degrees of sensitivities between conventional detection methods and molecular-based methods. The new technology is noted for increased sensitivity over the tradit...

In clinical metabolomics biomarker discovery is conducted by the complementary power of clinical study design and execution, molecular profiling technologies and an efficient bioinformatics strategy for biomarker search, verification and interpretation. This survey article gives a review of useful bioinformatics methods for biomarker discovery, addressing the problem of data preprocessing, the ...

Biomarkers are cornerstones of clinical medicine, and personalized medicine, in particular, is highly dependent on reliable and highly accurate biomarkers for individualized diagnosis and treatment choice. Modern omics technologies, such as genome sequencing, allow molecular profiling of individual patients with unprecedented resolution, but biomarkers based on these technologies often lack the...

I-SPY 2 (investigation of serial studies to predict your therapeutic response with imaging and molecular analysis 2) is a process targeting the rapid, focused clinical development of paired oncologic therapies and biomarkers. The framework is an adaptive phase II clinical trial design in the neoadjuvant setting for women with locally advanced breast cancer. I-SPY 2 is a collaborative effort amo...

With the development of molecular biology, some DNA-based technologies have showed great potentiality in promoting the efficiency of crop breeding program, protecting germplasm resources, improving the quality and outputs of agricultural products, and protecting the eco-environment etc., making their roles in modern agriculture more and more important. To better understand the application of DN...