Biological clocks are self-sustained oscillators that adjust their phase to the daily environmental cycles in a process known as entrainment. Molecular dissection and mathematical modeling of biological oscillators have progressed quite far, but quantitative insights on the entrainment of clocks are relatively sparse. We simultaneously tracked the phases of hundreds of synthetic genetic oscilla...

Circadian clocks influence numerous physiological and developmental functions in most if not all living organisms. Questions of how biological clocks operate have long intriguedbiologists.Howdocircadianclocks keep accurate time in the midst of constantly changing internal and external conditions, such as seasonally varying light/ dark cycles, large diurnal and seasonal temperature shifts, and a...

The crucial role of time-keeping has required organisms to develop sophisticated regulatory networks to ensure the reliable propagation of periodic behavior. These biological clocks have long been a focus of research; however, a clear understanding of how they maintain oscillations in the face of unpredictable environments and the inherent noise of biological systems remains elusive. Here, we r...

Although major progress has been made in uncovering the machinery that underlies individual biological clocks, much less is known about how multiple clocks coordinate their oscillations. We simultaneously tracked cell division events and circadian phases of individual cells of the cyanobacterium Synechococcus elongatus and fit the data to a model to determine when cell cycle progression slows a...

This article is the result of a case study of ergonomic work analysis carried out in a Brazilian airline company, focused on the safety of the activity of Airbus pilots from the company's national lines. The study was divided in three parts, each one with different approach. First step is how critical situations such as accidents and incidents are dealt with during flight. Then it comes to disc...

To survive and reproduce, a cell must process information from its environment own internal state respond accordingly, in terms of metabolic activity, gene expression, movement, growth, division differentiation. These signal–response decisions are made by complex networks interacting genes proteins, which function as biochemical switches clocks, other recognizable information-processing circuit...