Pathogenic mutations in BRCA1 or BRCA2 are only detected in 25% of families with a strong history of breast cancer, though hereditary factors are expected to be involved in the remaining families with no recognized mutation. Molecular characterization is expected to provide new insight into the tumor biology to guide the search of new high-risk alleles and provide better classification of the g...

BACKGROUND Alagille syndrome (AS) is regarded as the most common cause of chronic cholestasis in childhood associated with specific phenotypic features in western countries. This study was undertaken to investigate the significance of AS in Chinese children with chronic cholestasis and to describe its clinical and histological features. METHODS From October 2004 to January 2007, 157 children ...

IgG4-related disease is a recently established systemic condition. Tubulointerstitial nephritis is the most common renal manifestation. Glomerular lesions, particularly membranous glomerulonephritis, can develop simultaneously. Some patients present with serological renal dysfunction associated with elevated IgG or IgE levels and hypocomplementemia, while others are incidentally found to have a...

IgG4-related interstitial lung disease (IgG4-RILD), which is characterized by increased IgG4 levels, IgG4+ plasma cell infiltration and irregular whorled fibrosis, is a recently described lung disorder that belongs to the group of systemic fibroinflammatory IgG4-related diseases (IgG4-RD). The aim of the present study was to improve the current knowledge regarding the specific clinical and hist...

background: the clinical and pathological evaluation of oral lesions are very important in this field. the purpose of this study was to assess clinico- pathological agreement on 232 cases with oral lesion s.methods: the consecutive files of 232 patients with oral lesions from pathological laboratory archives of babol dental faculty and shahid beheshti hospital were reviewed and the data include...

non-hodgkin's lymphoma is the 3rd most common cancers in children. in the present study, to determine pathological and clinical features of this cancer, we reviewed records of 84 cases of non-hodgkin's lymphoma who were admitted to ali asghar and bahrami children hospitals from 1989 to 1996. 59% of cases had small non-cleaved cell (sncc) subtype of disease. 15% were lymphoblastic and ...

human papilloma virus (hpv) is considered as the main sexually transmitted etiological agent for the cause and progression of preneoplastic cervical lesions to cervical cancer. this study is discussing the prevalence of hpv and its genotypes in cervical lesions and invasive cervical cancer tissues and their association with various risk factors in women from varanasi and its adjoining areas in ...

Gastric cancer incidence and mortality varies between Mediterranean countries. As the diet is considered one of healthiest diet, gastric still fourth most common causes death from in Albania. The aim study was to analyze epidemiological, clinical pathological characteristic Albania, a country. Demographic, histopathological, data 306 treated Clinic Oncology at University Hospital Center Mother ...