Oxazine derivatives are significant class of heterocycle compounds, which has involved much synthetic attention due to their extensive variety of pharmacological activities. Oxazine is a heterocyclic compound can be formally derived from benzene, and its reduction products, by suitable substitution of carbon (and hydrogen) atoms by nitrogen and oxygen. In the last few years oxazine derivatives ...

endoplasmic reticulum has a critical role in the synthesis and folding of secretory and membrane proteins. high accumulation of proteins in er activates the unfolded protein response and glucose regulated protein 78 or gpr78 plays an essential role in this pathway.  unfolded protein response is activated in cancerous cells due to their adverse condition to survive and it has been shown that grp...

root-lesion disease, which is caused by pratylenchus loosi , is one of the most important diseases currently impacting iran tea plantations. this disease causes great economic crop impacts. northern provinces, which supply much of iran’s tea production, have been especially hard impact by root-lesion disease.the purpose of this study was to biological control the nematodes as one of the main se...

microorganisms are important components of soil. some soil filamentous fungi such aspenicilium produce many bioactive small molecules, or secondary metabolites, that range frombeneficial bioactive compounds to harmful toxins. in this study, the metabolites of threepenicillium species (p. goditanum, p. moldavicum and p. corylophilum) were extracted byadding ethyl acetate to liquid cultures. the ...

conclusions this study on a limited number of patients treated with adjutant anthracyclins-based regimens, revealed that her2/neu is not a unique strong predictor for outcome, thus according to combination of her2/neu status and other clinical factors, it is necessary to distinguish patients at high risk of recurrence. results her2/neu amplification was identified in 19 (38%) of 50 patients. no...

Background and Objective: Professional radiation workers are occupationally exposed to long-term low levels of ionizing radiation. Occupational health hazards from radiation exposure, in a large occupational segment of the population, are of special concern. Biological dosimetry can be performed in addition to physical dosimetry with the aim of individual dose assessment and biological effects....

Historically it has been shown repeatedly that single high doses of radiation do not allow a therapeutic differential between tumor and critical normal tissues but dose fractionation does. The purpose of conventional dose fractionation is to increase dose to the tumor while preserving normal tissue function. Tumors are generally irradiated with 2Gy dose per fraction delivered daily to a more or...

background: a new biological dosimeter based on methemoglobin level was developed in this study. materials and methods: methemoglobin level in erythrocytes from mice subjected to γ rays from a 60co source was detected using the methemoglobin kit. the dose range was from 0.5 to 8 gy and the dose rate was 0.5 gy/min. results: the results demonstrate that methemoglobin level increases with increas...