نتایج جستجو برای: biolayer interferometry

تعداد نتایج: 11333  

Journal: :Nanophotonics 2023

Abstract Chirality ( C ) is a fundamental symmetry property of objects. Detecting and distinguishing molecular chirality in the infrared spectrum important life sciences, biology, chemistry. In this paper, we demonstrate an achiral metasurface based on gaped dual-germanium-dimer array for enhanced mid-infrared chiral sensing under both circularly polarized light (CPL) linearly (LPL) excitations...

2016
Dorothee Weihrauch John G. Krolikowski Deron W. Jones Tahniyath Zaman Omoshalewa Bamkole Janine Struve Savin Pillai Paul S. Pagel Nicole L. Lohr Kirkwood A. Pritchard

Interferon regulatory factor 5 (IRF5) has been called a "master switch" for its ability to determine whether cells mount proinflammatory or anti-inflammatory responses. Accordingly, IRF5 should be an attractive target for therapeutic drug development. Here we report on the development of a novel decoy peptide inhibitor of IRF5 that decreases myocardial inflammation and improves vascular endothe...

Journal: :The international journal of biochemistry & cell biology 2012
Laura Aguilera Elaine Ferreira Rosa Giménez Francisco José Fernández Marta Taulés Juan Aguilar M Cristina Vega Josefa Badia Laura Baldomà

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a multifunctional housekeeping protein secreted by pathogens and involved in adhesion and/or virulence. Previously we reported that enterohemorrhagic (EHEC) and enteropathogenic (EPEC) Escherichia coli secrete GAPDH into the culture medium. This bacterial protein binds human plasminogen and fibrinogen and remains associated with Caco-2 cells u...

2015
Nicole A. Grieshaber Jeremiah S. Tattersall Johella Liguori Joseph N. Lipat Justin Runac Scott S. Grieshaber

The non-coding small RNA, IhtA expressed by the obligate intracellular human pathogen Chlamydia trachomatis modulates the translation of HctA, a key protein involved in replicative to infectious cell type differentiation. Using a combination of bioinformatics and mutagenesis we sought to identify the base pairing requirement for functional repression of HctA protein expression, with an eye to a...

Journal: :Biochemistry 2013
Subhashchandra Naik Susan Brock Narahari Akkaladevi Jon Tally Wesley McGinn-Straub Na Zhang Phillip Gao E P Gogol B L Pentelute R John Collier Mark T Fisher

Domain 2 of the anthrax protective antigen (PA) prepore heptamer unfolds and refolds during endosome acidification to generate an extended 100 Å β barrel pore that inserts into the endosomal membrane. The PA pore facilitates the pH-dependent unfolding and translocation of bound toxin enzymic components, lethal factor (LF) and/or edema factor, from the endosome to the cytoplasm. We constructed i...

2013
Patricia Estep Felicia Reid Claire Nauman Yuqi Liu Tingwan Sun Joanne Sun Yingda Xu

Advances in human antibody discovery have allowed for the selection of hundreds of high affinity antibodies against many therapeutically relevant targets. This has necessitated the development of reproducible, high throughput analytical techniques to characterize the output from these selections. Among these characterizations, epitopic coverage and affinity are among the most critical propertie...

2016
Miglė Kišonaitė Xuelu Wang Marko Hyvönen

Bone morphogenetic protein 2 (BMP-2) is a member of the transforming growth factor-β (TGF-β) signalling family and has a very broad biological role in development. Its signalling is regulated by many effectors: transmembrane proteins, membrane-attached proteins and soluble secreted antagonists such as Gremlin-1. Very little is known about the molecular mechanism by which Gremlin-1 and other DAN...

2015
Keersten M. Davis Anna L. Bitting Christine F. Markwalter Westley S. Bauer David W. Wright

This work outlines the synthesis of a non-emissive, cyclometalated Ir(III) complex, Ir(ppy)2(H2O)2(+) (Ir1), which elicits a rapid, long-lived phosphorescent signal when coordinated to a histidine-containing protein immobilized on the surface of a magnetic particle. Synthesis of Ir1, in high yields,is complete O/N and involves splitting of the parent cyclometalated Ir(III) chloro-bridged dimer ...

Journal: :Asian Pacific journal of allergy and immunology 2017
Witida Laopajon Nuchjira Takheaw Saichit Khummuang Tanyaluck Kampoun Kantinan Cheunsirikulchai Watchara Kasinrerk Supansa Pata

BACKGROUND Soluble CD147 (sCD147) is the shed form of membrane-bound CD147, which is involved in the regulation of cellular functions. The presence of sCD147 in body fluids is associated with several diseases. OBJECTIVE In this study, we aimed to establish antibody (Ab) biosensors for the simultaneous differential detection of the general and truncated forms of sCD147. METHOD By combining b...

2017
Betty Yuen Kwan Law Flora Gordillo-Martínez Yuan Qing Qu Ni Zhang Su Wei Xu Paolo Saul Coghi Simon Wing Fai Mok Jianru Guo Wei Zhang Elaine Lai Han Leung Xing Xing Fan An Guo Wu Wai Kit Chan Xiao Jun Yao Jing Rong Wang Liang Liu Vincent Kam Wai Wong

Cancers illustrating resistance towards apoptosis is one of the main factors causing clinical failure of conventional chemotherapy. Innovative therapeutic methods which can overcome the non-apoptotic phenotype are needed. The AMP-activated protein kinase (AMPK) is the central regulator of cellular energy homeostasis, metabolism, and autophagy. Our previous study showed that the identified natur...

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