نتایج جستجو برای: bioconjugate

تعداد نتایج: 260  

Journal: :Journal of Inorganic and Organometallic Polymers and Materials 2021

Despite the promising anti-cancer properties of polyoxometalates (POMs) compound, they have not yet been reported for clinical use due to their general toxicity. This study reports synthesis tocopherol succinate (TS)-polyoxomolybdate (POMo) conjugate (T2POMo) as a novel organic–inorganic hybrid POMo and evaluating its in vitro. The aim was introduce more potent derivative with less toxicity tha...

Journal: :Bioconjugate chemistry 2005
David Geho Nicholas Lahar Prem Gurnani Michael Huebschman Paul Herrmann Virginia Espina Alice Shi Julia Wulfkuhle Harold Garner Emanuel Petricoin Lance A Liotta Kevin P Rosenblatt

Protein microarray technologies provide a means of investigating the proteomic content of clinical biopsy specimens in order to determine the relative activity of key nodes within cellular signaling pathways. A particular kind of protein microarray, the reverse-phase microarray, is being evaluated in clinical trials because of its potential to utilize limited amounts of cellular material obtain...

Journal: :Indian journal of experimental biology 2014
Mazhari Bi Bi Zainab D N Madhusudhan H Raghavendra Syed G Dastager Agsar Dayanand

Most of the phenol compounds are toxic and have been considered as hazardous pollutants. Several physicochemical and biological methods are available to detect and monitor the phenol pollutants in water and soil. In the present study, phenol constituents of winery, paper and plastic industrial effluents were successfully detected employing tyrosinase-gold nanoparticles bioconjugate. The synthes...

2016
Veronika Kovač Ivana Kmetič Teuta Murati Marina Miletić Lidija Barišić

The bioorganometallic III containing trimethylene chain between ferrocene and resveratrol (3,5,4'-trihydroxystilbene, RSV) moieties connected via ester bond has been synthesized. The novel bioconjugate was characterized using IR and NMR (1H, 13C, COSY, NOESY, HMBC) spectroscopy, ESI-MS and HRMS. The RSV and ferrocene-RSV conjugate III were screened in vitro for their inhibitory effects against ...

2014
Alexandra M. Courtis Sofia A. Santos Yinghua Guan J. Adam Hendricks Balaram Ghosh D. Miklos Szantai-Kis Surya A. Reis Jagesh V. Shah Ralph Mazitschek

Small molecule fluorophores are indispensable tools for modern biomedical imaging techniques. In this report, we present the development of a new class of BODIPY dyes based on an alkoxy-fluoro-boron-dipyrromethene core. These novel fluorescent dyes, which we term MayaFluors, are characterized by good aqueous solubility and favorable in vitro physicochemical properties. MayaFluors are readily ac...

Journal: :Molecules 2010
Matteo Colombo Aldo Bianchi

In the last few years click chemistry reactions, and in particular copper-catalyzed cycloadditions, have been used intensively for the preparation of new bioconjugate molecules and materials applicable to biomedical and pharmaceutical areas. This review will be focused on conjugates of the tripeptide Arg-Gly-Asp formed by means of click chemistry reactions. This sequence is a well known binding...

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