The study aimed at determining the effect of acid modified porcine mucin powder on the release and permeation of insulin in transdermal patches. Various batches of insulin patches were prepared by solvent casting method using polysorbate 80 as emulsifying agent and acid treated and untreated mucin powders as base. The patches were evaluated for their physical properties, folding endurance, moi...

Background: Tolmetin (Tol) is a pyrrole acetic acid derivative that acts as a highly effective topical anti-inflammatory agent. Topical administration of Tol is effective for the management of ocular inflammations.The aim of this study was to formulate and improve a topical ophthalmic delivery system of Tol. Materials and methods: In the present study, ocular inserts of Tol were prepared using ...

Chitosan is currently proposed to be one of the most promising polymers in wound dressing development. Our research focuses on its potential as a vehicle for nano-delivery systems destined for burn therapy. One of the most important features of wound dressing is its bioadhesion to the wounded site. We compared the bioadhesive properties of chitosan with those of Carbopol, a synthetic origin pol...

Purpose: To develop mucoadhesive patches for buccal administration of metoprolol succinate and to evaluate their in vitro and in vivo bioadhesion. Methods: The mucoadhesive buccal patches were prepared by solvent casting technique using two different mucoadhesive polymers. The formulations were tested for in vitro drug permeation studies, buccal absorption, in vitro drug release studies, moistu...

Lorazepam a benzodiazepine drug is used as an antianxiety, sedative, hypnotic, and anticonvulsant drug. Bypassing the enterohepatic recirculation and first-pass metabolism of lorazepam by sublingual delivery of this drug may accelerate the onset of its action. The objective of this study was the formulation, optimization and in vitro characterization of mucoadhesive sublingual tablets of loraze...

The aim of the present investigation was to prepare and evaluate novel bioadhesive vaginal tablets containing clotrimazole loaded microspheres in order to provide long-term therapeutic activity at the site of infection. Tablets were prepared by incorporating drug loaded microspheres and using bioadhesive polymers hydroxypropylmethylcellulose, sodium carboxymethylcellulose and Carbopol. Microsph...

Accepted May 7, 2013 The aim of the present investigation was to prepare and evaluate novel bioadhesive vaginal tablets containing clotrimazole loaded microspheres in order to provide long-term therapeutic activity at the site of infection. Tablets were prepared by incorporating drug loaded microspheres and using bioadhesive polymers hydroxypropylmethylcellulose, sodium carboxymethylcellulose a...

The present work aims at developing mucoahesive tablets of ondansetron hydrochloride using bioadhesive polymers like carbopol-934, sodium alginate and gelatin. Tablets prepared by direct compression using different polymer with varying ratio were evaluated for hardness, friability, uniformity of weight, disintegration time, microenvironmental pH, bioadhesion and in vitro release. Hardness, fria...

Multiple emulsions (MEs) are intensively being studied for drug delivery due to their ability to load and increase the bioavailability of active lipophilic antioxidant, such as kojic dipalmitate (KDP). The aim of this study was to structurally characterize developed MEs by determining the average droplet size (Dnm) and zeta potential (ZP), performing macroscopic and microscopic analysis and ana...

Background: The freshwater cnidarian Hydra temporarily binds itself to numerous natural substrates encountered underwater, such as stones, leafs, etc. This adhesion is mediated by secreted material from specialized ectodermal modified cells at the aboral end of the animal. The means by which Hydra polyps attach to surface remain unresolved, despite the fact that Hydra is a classic model in deve...