The ATP-binding cassette (ABC) transporter GlnPQ is an essential uptake system for amino acids in gram-positive pathogens and related nonpathogenic bacteria. The transporter has tandem substrate-binding domains (SBDs) fused to each transmembrane domain, giving rise to four SBDs per functional transporter complex. We have determined the crystal structures and ligand-binding properties of the SBD...

ATP-binding cassette transporter G2 (ABCG2) is involved in the secretion of several compounds milk. The vitro and vivo interactions between tryptophan-related ABCG2 were investigated. tryptophan metabolome was determined by liquid chromatography-tandem mass spectrometry milk plasma from wild-type Abcg2?/? mice as well dairy cows carrying Y581S polymorphism (Y/S) noncarrier animals (Y/Y). milk-t...

Abstract Background Lipid transporters play an essential role in lipid delivery and distribution, but their influence on seed oil production oilseed crops is not well studied. Results Here, we examined the effect of two transporters, FAX1 ( fatty acid export1 ) ABCA9 ATP-binding cassette transporter subfamily A9 metabolism plant Camelina sativa . Overexpression (OE) increased weight size, with ...

Foam cell formation because of excessive accumulation of cholesterol by macrophages is a pathological hallmark of atherosclerosis, the major cause of morbidity and mortality in Western societies. Macrophages cannot limit the uptake of cholesterol and, therefore, depend on cholesterol efflux pathways for preventing their transformation into foam cells. Several ABC transporters, including adenosi...

The abbreviations used are: ABC, ATP-binding cassette; CFTR, cystic fibrosis transmembrane conductance regulator; ER, endoplasmic reticulum; IP, immunoprecipitation; MHC, major histocompatibility complex; NBD, nucleotide-binding domain; PBS, phosphatebuffered saline; PCR, polymerase chain reaction; P-gp, P-glycoprotein; TAP, transporter associated with antigen processing; TMD, transmembrane dom...

Foam cell formation because of excessive accumulation of cholesterol by macrophages is a pathological hallmark of atherosclerosis, the major cause of morbidity and mortality in Western societies. Macrophages cannot limit the uptake of cholesterol and, therefore, depend on cholesterol efflux pathways for preventing their transformation into foam cells. Several ABC transporters, including adenosi...