Purpose – Building information modelling (BIM) in facilities management (FM) applications is an emerging area of research based on the theoretical proposition that BIM information, generated and captured during the lifecycle of a facility, can improve its management. Using this proposition as a starting point, the purpose of this paper is to investigate the value of BIM and the challenges affec...

The adoption of building information modeling (BIM) is increasing in the construction industry. However, quantity surveyors are slow in adoption compared to other professions due to lack of awareness of the BIM’s potential in their profession. It is still unclear on how BIM application can enhance quantity surveyors’ work performance and project performance. The aim of this research is to ident...

a r t i c l e i n f o Keywords: Building information modeling BIM promises BIM implementation Experimentation Cultural historical activity theory Evolutionary theory of innovation Building information modeling (BIM) refers to a combination or a set of technologies and organizational solutions that are expected to increase interorganizational and disciplinary collaboration in the construction in...

Trophic factor deprivation (TFD) activates c-Jun N-terminal kinases (JNKs), culminating in coordinate AP1-dependent transactivation of the BH3-only BCL-2 proteins BIM(EL) and HRK, which in turn are critical for BAX-dependent cytochrome c release, caspase activation, and apoptosis. Here, we report that TFD caused not only induction but also phosphorylation of BIM(EL). Mitochondrially localized J...

The pro-apoptotic Bcl-2-family protein Bim belongs to the BH3-only proteins known as initiators of apoptosis. Recent data show that Bim is constitutively inserted in the outer mitochondrial membrane via a C-terminal transmembrane anchor from where it can activate the effector of cytochrome c-release, Bax. To identify regulators of Bim-activity, we conducted a search for proteins interacting wit...

Recently, Building Information Modeling (BIM) technology has attracted much attention in the Architecture, Engineering, and Construction (AEC) industry. Despite the growing interest in BIM technology, the benefits of BIM have not yet been fully realized during the course of implementation of BIM because of its low adoption rate among architects. Therefore, it is significant important in success...

Building Information Modelling (BIM) is considered an innovation for construction, with the potential to digitise various construction processes. Being an innovation, it affects and is affected by organisational aspects. At the same time, innovations are better observed at a project level. This study connects intraand interorganisational levels mobilised during BIM implementation. To explore th...

Paclitaxel is used to treat breast cancers, but the mechanisms by which it induces apoptosis are poorly understood. Consequently, we have studied the role of the FoxO transcription factors in determining cellular response to paclitaxel. Western blotting revealed that in a panel of nine breast cancer cell lines expression of FoxO1a and FoxO3a correlated with the expression of the pro-apoptotic F...

Considerable amount of research has been developed that investigate the benefits of Building Information Modelling (BIM) for design and construction. However, as suggested in the UK Government Strategy, the relevant gains and difficulties related to the adoption of BIM in the operational stages of the project life cycle are considerably less explored in the available literature. In this respect...

Aberrant changes in the expression of the pro-apoptotic protein, BCL-2-like 11 (BIM), can result in either impaired or excessive apoptosis, which can contribute to tumorigenesis and degenerative disorders, respectively. Altering BIM pre-mRNA splicing is an attractive approach to modulate apoptosis because BIM activity is partly determined by the alternative splicing of exons 3 or 4, whereby exo...