c-Secretase inhibitors (GSIs) are being actively repurposed as cancer therapeutics based on the premise that inhibition of NOTCH1 signaling in select cancers is therapeutic. Using novel assays to probe effects of GSIs against a broader panel of substrates, we demonstrate that clinical GSIs are pharmacologically distinct. GSIs show differential profiles of inhibition of the various NOTCH substra...

BACKGROUND Intravascular irradiation with beta-emitters has been proposed for inhibition of restenosis in coronary arteries after balloon angioplasty or stent implantation. Previous studies have shown the effectiveness of gamma-radiation to prevent recurrent restenosis, even in the presence of an implanted stent. The limited range of beta-particles compared with gamma-radiation, however, opens ...

In this paper we analyze metastability and nucleation in the context of Kawasaki dynamics for two-dimensional Ising lattice gas at very low temperature with periodic boundary conditions. Let $\beta>0$ be inverse let $\Lambda\subset\Lambda^\beta\subset\mathbb{Z}^2$ two boxes. We consider asymptotic regime corresponding to limit as $\beta\rightarrow\infty$ finite volume $\Lambda$ $\lim_{\beta\rig...

We consider the soft-core Widom-Rowlinson model for particles with spins and holes, on a Cayley tree of order $d$ (which has $d + 1$ nearest neighbours), depending repulsion strength $\beta$ between different signs an activity parameter $\lambda$ particles. analyse Gibbsian properties time-evolved intermediate Gibbs measure static model, under spin-flip time evolution, in regime large $\beta$. ...

We assess how well next-generation neutrinoless double beta decay and normal neutrino beta decay experiments can answer four fundamental questions. ~1! If neutrinoless double beta decay searches do not detect a signal, and if the spectrum is known to be inverted hierarchy, can we conclude that neutrinos are Dirac particles? ~2! If neutrinoless double beta decay searches are negative and a next-...

Though the general appearance and the cellular composition of the pancreatic islets of the Mongolian gerbil (Meriones unguiculatus) conformed to those of most other rodent species, some peculiar ultrastructural details were found. Thus there were diversiform, mainly vesicular particles with varying electron opacity in these islets. The vesicular particles showed a clear association to cilia whi...

Several studies have shown that macro micro porous bioceramics ectopically implanted promote bone tissue formation. This study aims at investigating the inflammatory response towards biphasic calcium phosphate (BCP) ceramic micro particles. BCP composed of hydroxyapatite (HA) and beta-tricalcium phosphate, HA/beta -TCP ratio of 50/50, were prepared by sintering at 1200 degrees C for 5 h. After ...