نتایج جستجو برای: bet analysis
تعداد نتایج: 2831125 فیلتر نتایج به سال:
The T-box transcription factor, T-bet promotes the differentiation of short-lived effector CD8(+) T cells at the expense of central memory cells. How T-bet mediates these effects, and whether they are directly caused by T-bet alone are unknown, because expression of T-bet requires stimulation of the T cell by inflammatory and growth cytokines, which may have T-bet-independent functions involvin...
The APOBEC3 cytidine deaminases are part of the intrinsic defense of cells against retroviruses. Lentiviruses and spumaviruses have evolved essential accessory proteins, Vif and Bet, respectively, which counteract the APOBEC3 proteins. We show here that Bet of the Prototype foamy virus inhibits the antiviral APOBEC3C activity by a mechanism distinct to Vif: Bet forms a complex with APOBEC3C wit...
T-bet plays an important role in immunoregulation; it induces the differentiation of Th1 together with the homeobox transcription factor gene Hlx. Recent studies show that T-bet and Th1-associated factors are critical in regulating tumor development. However, the contributions of Hlx in the occurrence and development of cancer remain unknown. In this study, the Hlx, T-bet, Runx3, and IFN-γ were...
Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells.
The transcription factor T-bet (Tbx21) plays a major role in adaptive immunity and is required for optimal IFN-gamma production by DCs. Here we demonstrate an essential function for T-bet in DCs in controlling inflammatory arthritis. We show that collagen antibody-induced arthritis (CAIA), a model of human RA, is a bipartite disease characterized by an early innate immune system component intac...
Previously, defined naturally occurring isoforms of allergenic proteins were classified as hypoallergens and therefore suggested as an agent for immunotherapy in the future. In this paper, we report for the first time the molecular background of hypoallergenicity by comparing the immunological behavior of hyperallergenic Betula verrucosa major Ag 1a (Bet v 1a) and hypoallergenic Bet v 1d, two i...
The protein Bet v 1 represents the main cause for allergic reactions to birch pollen in Europe and North America. Structurally homologous isoforms of Bet v 1 can have different properties regarding allergic sensitization and Th2 polarization, most likely due to differential susceptibility to proteolytic cleavage. Using NMR relaxation experiments and molecular dynamics simulations, we demonstrat...
در کار پژوهشی حاضر نانو ذرات cdzn2b2o6 و گونه های دوپه شده به صورت cd(1-x)smxzn2b2o6 (x=0.05, 0.10, 0.15) و cd(1-x) eux zn2b2o6 (x=0.05, 0.10, 0.15) وcd(1-x)smx/2eux/2 zn2b2o6 (x=0.05, 0.10, 0.15) به روش «همرسوبی» سنتز شده است . سپس ساختار و خواص آن ها با بهره گیری از xrd، ft-ir، uv-vis ، edx ، sem ، map analysis،bet و fluorescenceمورد مطالعه وبررسی قرار گرفت. نتایج آنالیز xrd نشان داد که در سی...
Elusive bugs can be particularly expensive because they often survive testing and are released in a deployed system. They are characterized as involving a combination of properties. One approach to their detection is bounded exhaustive testing (BET). This paper describes how to implement BET using a variation of JUnit, called BETUnit. The idea of a BET pattern is also introduced. BET patterns d...
Background Birch pollen-allergic subjects often develop Bet v 1-specific IgE that cross-reacts with homologous food allergens. Bet v 1 and its homologs in pollen and food display exclusively conformational epitopes. We established a system to specifically analyze epitope cross-reactivity of Bet v 1-related allergens. The enzyme norcoclaurine synthase (NCS) from Thalictrum flavum is structurally...
Malignant brain tumors are the most common solid tumors in children. The overall prognosis for this group of patients is still poor, emphasizing the importance of more effective therapies. Betulinic acid (Bet A) has been described as a novel cytotoxic compound active against melanoma and neuroblastoma cells. Here we report that Bet A was active against medulloblastoma and glioblastoma cell line...
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