The production of lung adenomas in strain A mice following multiple injections of 17 alkyl halides and of 3 base analogs was investigated. A slight but significant increase in the average number of lung tumors per mouse was noted following the administration of methyl iodide, n and i-propyl iodide, secand tert-butyl chloride, i-, sec-, and tert-butyl bromide, and nand sec-butyl iodide. The admi...

a number of n-arylmethyl substituted indole derivatives have been synthesized and their effectiveness against adp and arachidonic acid induced platelet aggregation in human plasma was determined. the desired compounds were synthesized by reacting the appropriate aniline derivative with isatin (or substituted isatin) to form the corresponding imine structures. the so formed compound was then act...

The recent years have witnessed the development of metal-catalyzed reductive carboxylation of organic (pseudo)halides with CO2 as C1 source, representing potential powerful alternatives to existing methodologies for preparing carboxylic acids, privileged motifs in a myriad of pharmaceuticals and molecules displaying significant biological properties. While originally visualized as exotic cross-...

Based on the core structure of diflunisal drug, herein, we report a resembling series biaryl analogs (3a–j) containing halogens, nitro, and methoxy substituents. They were designed synthesized via Suzuki–Miyaura cross-coupling reaction using Pd (OH)2 as catalyst at temperature 65 °C with an intent to obtain improved safer anti-inflammatory analgesic agents. transformation is most significant am...