Benzocaine is a local anesthetic used for different pain treatments. Including it in various cyclodextrins one can increase the solubility of this drug. Several inclusion compounds of β-cyclodextrin (β-CD) with benzocaine, prepared by kneading and coprecipitation methods, were investigated. In order to understand the inclusion process mechanisms FT IR spectroscopic investigation and molecular m...

When properly given, local anesthetics are generally free of side effects. However, systemic or localized toxicity occurs with accidental intravascular injection or by injecting excessive doses (especially intrathecally). Additionally, other adverse effects occur with certain agents, e.g., allergic reactions to the amino-esters, and methemoglobinemia with benzocaine and with high doses of prilo...

KEY POINTS Zebrafish provide a unique opportunity to investigate in vivo sensory transduction in mature hair cells. We have developed a method for studying the biophysical properties of mature hair cells from the lateral line of juvenile zebrafish. The method involves application of the anaesthetic benzocaine and intubation to maintain ventilation and oxygenation through the gills. The same app...

In the title compound, C(11)H(10)N(2)O, the dicyano-ethyl-ene portion has an anti conformation. The crystal structure features non-classical C-H⋯N and C-H⋯O inter-actions.

Toxic methemoglobinemia is an uncommon blood disorder induced by exposure to certain oxidizing agents and drugs. In severe cases, this condition may rapidly lead to major cardiopulmonary compromise and constitutes an emergency requiring prompt recognition and early management. We report an unusual case of severe toxic methemoglobinemia following wide cutaneous application of a pomade containing...