نتایج جستجو برای: benzimidazole synthesis
تعداد نتایج: 411590 فیلتر نتایج به سال:
The key step in the synthesis of new five, six and seven-membered alicyclic ring [1,2-a]-fused bioreductive benzimidazolequinones was radical cyclisation. Six and seven-membered tributyltin hydride-mediated homolytic aromatic substitutions of nucleophilic N-alkyl radicals onto the benzimidazole-2-position occurred in high yields (63-70 %) when quaternising the pyridine-like 3-N of imidazole wit...
A new, efficient method for the synthesis of 2-aryl substituted benzimidazole by using silica supported periodic acid (H5IO6-SiO2) as a catalyst has been developed. The salient feature of the present method includes mild reaction condition, short reaction time, high yield and easy workup procedure. The synthesized benzimidazoles exhibited potent anticancer activity against MCF7 and HL60 cell li...
The synthesis of benzimidazoles by intermolecular cyclization reaction of 2-iodoanilines with nitriles has been developed. These reactions proceeded without the aid of any transition metals or ligands and just using KOBu(t) as the base. A variety of substituted benzimidazole derivatives can be synthesized by the approach.
The most of drugs containing Benzimidazole ring is a prominent structural motif found in numerous therapeutically active compounds. and its synthetic analogues have been to exhibit industrial, agricultural biological application such as antitubercular, anti-inflammatory, analgesic, anticancer, anticoagulant, well good antifungal anti microbial activity. Recent advances technology considers micr...
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