Long-term bed-rest is used to simulate the effect of spaceflight on the human body and test different kinds of countermeasures. The 2nd Berlin BedRest Study (BBR2-2) tested the efficacy of whole-body vibration in addition to high-load resisitance exercise in preventing bone loss during bed-rest. Here we present the protocol of the study and discuss its implementation. Twenty-four male subjects ...

Background: Decubitus ulcers occur due to prolonged pressure and friction on the skin, especially in bone protrusion area which causes decreased blood circulation then local tissue is ischemic, hypoxic, develops into necrosis causing decubitus ulcers. The most effective nursing interventions prevent massage. Objective: This literature review aims find out type of massage prevention bedrest pati...

Costameres are mechano-sensory sites of focal adhesion in the sarcolemma that provide a structural anchor for myofibrils. Their turnover is regulated by integrin-associated focal adhesion kinase (FAK). We hypothesized that changes in content of costamere components (beta 1 integrin, FAK, meta-vinculin, gamma-vinculin) with increased and reduced loading of human anti-gravity muscle would: (i) re...

Electromagnetic spectra reduce melatonin production and delay the nadirs of rectal temperature and heart rate. Seven healthy men (16-22 yrs) completed 4 permuted sessions. The control session consisted of a 24-hours bedrest at < 30 lux, 18 degrees C, and < 50 dBA. In the experimental sessions, either light (1500 lux), magnetic field (16.7 Hz, 0.2 mT), or infrared radiation (65 degrees C) was ap...

BACKGROUND Though poorly defined, hypersomnia is associated with negative health outcomes and new-onset and recurrence of psychiatric illness. Lack of definition impedes generalizability across studies. The present research clarifies hypersomnia diagnoses in bipolar disorder by exploring possible subgroups and their relationship to prospective sleep data and relapse into mood episodes. METHOD...

When heart rate is “too high,” perhaps the reflex therapeutic response is to give -blockers. These drugs are certainly used to treat the excessive heart rate responses to standing seen in the Postural Orthostatic Tachycardia Syndrome (POTS).1 In this context, since POTS was defined as an identifiable syndrome, ideas abut inadequate peripheral vasoconstriction, altered blood volume regulation, a...