PER2, a key molecular component of the mammalian circadian clock, is expressed rhythmically in many brain areas and peripheral tissues in mammals. Here we review findings from our work on the nature and regulation of rhythms of expression of PER2 in two anatomically and neurochemically defined subregions of the central extended amygdala, the oval nucleus of the bed nucleus of the stria terminal...

Limbic dysfunction and hypothalamo-pituitary-adrenocortical (HPA) axis dysregulation are key features of affective disorders. The following review summarizes our current understanding of the relationship between limbic structures and control of ACTH and glucocorticoid release, focusing on the hippocampus, medial prefrontal cortex and amygdala. In general, the hippocampus and anterior cingulate/...

7 8 Department of Anesthesiology and Perioperative Medicine and Center for Neuroscience 9 Studies, Queen’s University, Kingston, Ontario, Canada, K7L 3N6 10 11 INSERM, U862, Neurocentre Magendie, Centre National de la Recherche Scientifique, 12 Bordeaux Institute of Neuroscience, UMR 5227, Université de Bordeaux, Bordeaux, F-33000, 13 France 14 15 Abbreviated title: Regulation of synaptic trans...

I am currently engaged in an NIH-funded research project with faculty at The University of Virginia and North Carolina State University that investigates the transgenerational effects of the plastic component, bisphenol A (BPA), on gene transcription in two regions of the brain: the medial preoptic area (MPOA) of the hypothalamus and the bed nucleus of the stria terminalis (BNST). My participat...

Fifteen years ago epinephrine cells were shown to be present in the medulla oblongata of the rat. These cell groups (C1 and C2) were thought to supply the epinephrine innervation in the rest of the central nervous system. In this study I demonstrate the presence of epinephrine-producing neurons in the forebrain of the young rat. Neurons that are immunopositive for phenylethanolamine N-methyltra...

The mu, delta, and kappa opioid receptors are the three main types of opioid receptors found in the central nervous system (CNS) and periphery. These receptors and the peptides with which they interact are important in a number of physiological functions, including analgesia, respiration, and hormonal regulation. This study examines the expression of mu, delta, and kappa receptor mRNAs in the r...