Networks of GE/GE queues provide bursty traffic, and are motivated in work by Kouvatsos et al. We provide an improved approximation method using processes defined on bands of queue lengths that can be employed within systems that exhibit significant correlation. These bands allow construction of a piece-wise queue length dependent arrival process, which improves the match between the approximat...

We develop approximate solutions for the equilibrium queue length probability distribution of queues in open Markovian networks by considering each queue independently, constructing its arrival process as the join of each contributing queue's departing traffic. Without modulation and non-unit batches, we would only need to consider mean internal traffic rates, modelling each queue as M/M/1 to g...

Motivated by practical applications, chiefly clinical trials, we study the regret achievable for stochastic bandits under the constraint that the employed policy must split trials into a small number of batches. We propose a simple policy that operates under this contraint and show that a very small number of batches gives close to minimax optimal regret bounds. As a byproduct, we derive optima...

The performance of batched search when applied to index sequential files is studied. Analysis provides exact formulae for the cost of searching when batching is applied as a function of the magnitude of the query and time. The analysis takes into account (a) accesses to the overflow area only, and (b) accesses to both primary and overflow area, as well as whether the records of the query are (a...

nanoparticles have been at the center of research focus as a new promising material for the treatment of cancer in recent years. although many chemotherapy drugs for cancer treatment are available, their potential toxicity is the main point of concern. on the other hand, the conventional chemotherapeutic approach has not been found to be very efficient in colorectal cancer (crc) as the drug mol...

since its original conception in 1959, by nobel physicist richard p feynman, the notion of nanotechnology and its potential ramifications have not only created fascination,but also intense scientific efforts and scrutiny. one of the most promising applications of nanotechnology is in the context of medicine. due to their unique size-dependent properties nanomaterials such as nanoparticles offer...

background: several multiphase flow analyses have been developed to predict the fate of particles used in inhalation drug delivery; however, the collapse of droplets during their passage through respiratory tract has not been investigated. objective: to assess the probability of droplet collapse in the upper respiratory tract. methods: a 3d model of mouth-to-second generation airway after the t...

conclusions it was shown that combination of pectin and eudragits can relatively control drug release in the upper gi. on the other hand, pectin degraded in the presence of pectinase and formulations were susceptible to the colonic media. results it was shown that in the presence of pectin, formulations without erl had a relative resistance to drug release in sgf. pellets containing pectin and ...

A common form of a hyper-heuristic is a method that controls a search process which uses neighbourhood operators. There have many studies showing that hyper-heuristics are reusable for solving unseen problem instances not only from a particular domain but also different problem domains without requiring any change. However, generally hyper-heuristics have been considered as part of time-contrac...

the field of vaccinology provides excellent promises to control different infectious and non-infectious diseases. genetic immunization as a new tool in this area by using naked dna has been shown to induce humoral as well as cellular immune responses with high efficiency. this demonstrates the enormous potential of this strategy for vaccination purposes. dna vaccines have been widely used to de...