The CRISPR system holds much promise for successful genome engineering, but therapeutic, industrial, and research applications will place high demand on improving the specificity and efficiency of this tool. CT-Finder (http://bioinfolab.miamioh.edu/ct-finder) is a web service to help users design guide RNAs (gRNAs) optimized for specificity. CT-Finder accommodates the original single-gRNA Cas9 ...

The work discussed in this article concentrates on applying a laser range finder instead of a silicon retina. The laser range finder is maximal focused at any time, but therefore a lowresolution total-scene-image, available with camera-like devices from scratch on, cannot be used here. By adapting a couple of algorithms, the edge-scanning module steering the laser range finder is able to trace ...

Even when the Global Positioning System (GPS) signal is blocked, a rate gyroscope (gyro) north finder is capable of providing the required azimuth reference information to a certain extent. In order to measure the azimuth between the observer and the north direction very accurately, we propose a multi-position non-continuous rotation gyro north finding scheme. Our new generalized mathematical m...

During the last two decades, product labeling has become an increasingly used policy tool, particularly with respect to the provision of health and environmerrtd information. Theory holds that the flow of information among market participants plays a critical role in the efficient operation of markets. This paper explores the role of product labeling policy in ameliorating two potential market ...

Public policy is becoming increasingly stringent with respect to the environmental impacts of modern products. To respond to this tightened scrutiny, product designers must innovate to lower the environmental footprints of their concepts. Design for Environment (DfE) is a field of product design methodology that includes tools, methods and principles to help designers reduce environmental impac...