Oxidativephosphorylation (OXPHOS), themajor energy-producing pathway inaerobicorganisms, includesprotein subunits encoded by both mitochondrial (mt) and nuclear (nu) genomes. How these independent genomes have coevolved is a long-standing question in evolutionary biology. Although mt genes evolve faster than most nu genes, maintenance of OXPHOS structural stability and functional efficiency may...

Previous work has shown that nude (nu/nu) mice additionally immunosuppressed by splenectomy, sublethal irradiation, and treatment with antiasialo GM1 antiserum (SIA-nu/nu mice) have no detectable natural killer activity and allow the growth of human malignant lymphoblasts. We show here that all SIA-nu/nu mice engrafted intravenously with 5 x 10(6) malignant lymphoblasts originally derived from ...

‎Let $\Omega_X$ be a bounded‎, ‎circular and strictly convex domain in a complex Banach space $X$‎, ‎and $\mathcal{H}(\Omega_X)$ be the space of all holomorphic functions from $\Omega_X$ to $\mathbb{C}$‎. ‎The growth space $\mathcal{A}^\nu(\Omega_X)$ consists of all $f\in\mathcal{H}(\Omega_X)$‎ ‎such that $$|f(x)|\leqslant C \nu(r_{\Omega_X}(x)),\quad x\in \Omega_X,$$‎ ‎for some constant $C>0$‎...

w: LF (nu) 67-9 (11 1)* 53-2 (7 3) HF (nu) 32-1 (8 1)* 42-7 (4 9) LF/HF 2-33 (0 88)* 1-28 (0-21) Stage 2 non-REM sleep: LF (nu) 39-9 (13-9) 36-2 (15-5) HF (nu) 60-1 (15-2) 57.3 (11-2) LF/HF 0-84 (0 63) 0-76 (0 48) Stage 3-4 non-REM sleep: LF (nu) 26-9 (11 1) 25-9 (8-6) HF (nu) 73-1 (14 6) 66-2 (11-6) LF/HF 0 47 (0 41) 0-46 (0-32) REM sleep: LF (nu) 56-3 (12 8) 53 2 (16-6) HF (nu) 43 7 (8 3) 41 ...

BACKGROUND Tissues undergoing a chronic inflammatory process, such as the synovium in rheumatoid arthritis, are characterized by the infiltration of lymphocytes of different subsets and activation of monocyte/macrophages. Interleukin-1 (IL-1), a monocyte/ macrophage product that stimulates synovial fibroblasts to produce matrix metalloproteinases (MMPs), prostaglandins, and other cytokines, als...

Extracellular adenosine production by the GPI-anchored Ecto-5'-Nucleotidase (Ecto-5'-Nu) plays an important role in the cardiovascular system, notably in defense against hypoxia. It has been previously suggested that HMG-CoA reductase inhibitors (HRIs) could potentiate the hypoxic stimulation of Ecto-5'Nu in myocardial ischemia. In order to elucidate the mechanism of Ecto-5'-Nu stimulation by H...