Silybum marianum (L.) Gaertn. is an important medicinal plant of family Compositae, commonly known as Milk-thistle, or St. Mary’s thistle. The plant and its extracts are reported to possess hepatoprotective, antioxidant, [1] anticancer, [2] antiinflammatory and antidiabetic properties. It contains flavonolignan Silymarin, which is an important bioactive principle having anticancer, antiinflamma...

green synthesis of nanoparticles, as fundamental building blocks of nanotechnology, has recently attracted considerable attention. silver nanoparticles have unique physiochemical, biological and environmental properties which make them useful in a wide range of applications. in the present paper we report our research results on biosynthesis of silver nanoparticles from silver precursor using m...

Abstract The current study aimed to evaluate the effect of adding different levels milk thistle Silybum marianum cereal powder ration on productive and physiological performance laying hens. experiment was performed from age 49 weeks 64 hens age. A total 81 were randomly distributed three treatments each treatment with replicates nine birds in replicate. experimental as following : Treatment 1 ...

One hundred forty four 10-day old male Arbor Acres (320±5g) broiler chicks were used to compare the responses in liver function to dietary supplementation of milk thistle (Silybum marianum), artichoke (Cichorium intybus) and olive (Olea europaea) extracts with gemfibrozil and atorvastatin, in broiler chickens fed with a lipogenic diet. Birds raised in the standard experimental conditions and re...

We show that silymarin, a polyphenolic flavonoid isolated from milk thistle (Silybum marianum), inhibits cytokine mixture (CM: TNF-α, IFN-γ, and IL-1β)-induced production of nitric oxide (NO) in the pancreatic beta cell line MIN6N8a. Immunostaining and Western blot analysis showed that silymarin inhibits iNOS gene expression. RT-PCR showed that silymarin inhibits iNOS gene expression in a dose-...

Silymarin is a hepatoprotective mixture of flavonolignans and flavonoids extracted from the seeds of milk thistle (Silybum marianum L. Gaertn). This study investigates the effect of major bioactive constituents from silymarin, silybin A, silybin B, isosilybin A, isosilybin B, silydianin, silychristin, isosilychristin, and taxifolin, on the expression of ABCA1, an important cholesterol efflux tr...

The liver is one of the major organs of the human body which plays an important role in the detoxification of xenobiotics, among which are mentioned alcohol, stimulants, drugs. The parenchymal cells of the liver called hepatocytes which have high ability to regenerate, are a main component of this organ. There are many factors that damage the liver e.g. drugs, chemicals, viral infections, autoi...

Thistle oil (INCI: Silybum marianum seed oil) is known as an anti-oxidant, moisturizing and skin regenerating cosmetic raw material. Nanoemulsions are a new form of cosmetic product showing very good user properties (ease of spreading over the skin with no greasy feeling). Moreover, due to their structure, they can also transport both hydrophilic and hydrophobic active substances to the skin. T...