نتایج جستجو برای: b5

تعداد نتایج: 2878  

2017
Remco Bouckaert Brenna C. Simons Henrik Krarup T. Max Friesen Carla Osiowy

BACKGROUND Indigenous populations of the circumpolar Arctic are considered to be endemically infected (>2% prevalence) with hepatitis B virus (HBV), with subgenotype B5 (formerly B6) unique to these populations. The distinctive properties of HBV/B5, including high nucleotide diversity yet no significant liver disease, suggest virus adaptation through long-term host-pathogen association. METHO...

Journal: :Journal of virology 2007
Lydia Aldaz-Carroll Yuhong Xiao J Charles Whitbeck Manuel Ponce de Leon Huan Lou Mikyung Kim Jessica Yu Ellis L Reinherz Stuart N Isaacs Roselyn J Eisenberg Gary H Cohen

Immunization against smallpox (variola virus) with Dryvax, a live vaccinia virus (VV), was effective, but now safety is a major concern. To overcome this issue, subunit vaccines composed of VV envelope proteins from both forms of infectious virions, including the extracellular enveloped virion (EV) protein B5, are being developed. However, since B5 has 23 amino acid differences compared with it...

2014
Nadia Petlakh Co Ryan M. Young Amanda L. Smeigh Michael R. Wasielewski Brian M. Hoffman

We report here that photoinitiated electron flow involving a metal-substituted (M = Mg, Zn) myoglobin (Mb) and its physiological partner protein, cytochrome b5 (cyt b5) can be "symmetrized": the [Mb:cyt b5] complex stabilized by three D/E → K mutations on Mb (D44K/D60K/E85K, denoted MMb) exhibits both oxidative and reductive ET quenching of both the singlet and triplet photoexcited MMb states, ...

2005
B. Zielińska-Psuja J. Orlowski A. Plewka M. Kaminski J. Kowalówka-Zawieja

This study aimed at evaluating the effect of acetylsalicylic acid (ASA) (150 and 300 mg/kg b.w.) on urinary trichloroethanol and trichloroacetic acid excretion and the liver cytochrome P-450-dependent monooxygenase system (MFO) in rats treated with trichloroethylene (TRI) alone or with xylene (XYL) at a concentration of 4.5 mmol/m air. The study has shown that xylene equally decreased trichloro...

Journal: :The Journal of Cell Biology 1979
E D Jarasch J Kartenbeck G Bruder A Fink D J Morré W W Franke

Fractions of plasma membranes, Golgi apparatus, endoplasmic reticulum (ER), and nuclear envelope were isolated from rat liver and were characterized by electron microsocpe and biochemical methods. The purity of the fractions was controlled by morphometry and by marker enzyme activities. Amounts of cytochromes b5, P-450, and P-420 were measured, as well as the NADPH- and NADPH-cytochrome c reduc...

Journal: :Tissue antigens 1979
D Adorno P P Pezzi S Bonini C Masala M A Amendolea C U Casciani

Correspondence HLA B5 and Behget's disease SIR, May we draw your attention again to the inheritance of the HLA B5 antigen and its association with Behcet's disease? The association of the HLA B5 and especially its Bw5l split' 2 with Behcet's disease was established in Japan'`3 and Turkey.4'5 There is also a weak association of B5 and Beh,et's disease in British male patients.5'6 There has been ...

Journal: :The Journal of biological chemistry 1998
M F Belcourt W F Hodnick S Rockwell A C Sartorelli

NADH:cytochrome b5 reductase activates the mitomycins to alkylating intermediates in vitro. To investigate the intracellular role of this enzyme in mitomycin bioactivation, Chinese hamster ovary cell transfectants overexpressing rat NADH:cytochrome b5 reductase were generated. An NADH:cytochrome b5 reductase-transfected clone expressed 9-fold more enzyme than did parental cells; the levels of o...

Journal: :The Journal of Biological Chemistry 2008
Robert D. Finn Lesley A. McLaughlin Sebastien Ronseaux Ian Rosewell J. Brian Houston Colin J. Henderson C. Roland Wolf

In vitro, cytochrome b5 modulates the rate of cytochrome P450-dependent mono-oxygenation reactions. However, the role of this enzyme in determining drug pharmacokinetics in vivo and the consequential effects on drug absorption distribution, metabolism, excretion, and toxicity are unclear. In order to resolve this issue, we have carried out the conditional deletion of microsomal cytochrome b5 in...

2013
Colin J. Henderson Lesley A. McLaughlin Roland Wolf

We previously described the development of genetic models to study the in vivo functions of the hepatic cytochrome P450 (P450) system, through the hepatic deletion of either cytochrome P450 oxidoreductase [POR; HRN (hepatic reductase null) line] or cytochrome b5 [HBN (hepatic cytochrome b5 null) line]. However, HRN mice still exhibit low levels of mono-oxygenase activity in spite of the absence...

2009
Kim L. Roberts Adrien Breiman Gemma C. Carter Helen A. Ewles Michael Hollinshead Mansun Law Geoffrey L. Smith

The extracellular enveloped virus (EEV) form of vaccinia virus (VACV) is surrounded by two lipid envelopes. This presents a topological problem for virus entry into cells, because a classical fusion event would only release a virion surrounded by a single envelope into the cell. Recently, we described a mechanism in which the EEV outer membrane is disrupted following interaction with glycosamin...

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