Peptide vaccines incorporating B- and T-cell epitopes have shown promise in the context of various cancers infections. These are relatively simple to manufacture, but more immunogenic formulations considered a priority. We developed tetrabranched derivatives for this purpose based on novel peptide welding technology (PWT). PWTs provide molecular scaffolds efficient synthesis ultrapure dendrimer...

Epstein-Barr virus is a very common human virus that infects 90% of human adults. EBV replicates in epithelial and B cells and causes infectious mononucleosis. EBV infection is also linked to various cancers, including Burkitt's lymphoma and nasopharyngeal carcinomas, and autoimmune diseases such as multiple sclerosis. Currently, there are no effective drugs or vaccines to treat or prevent EBV ...

Contagious human coronavirus belong to family Coronaviridae and infects respiratory system causing the disease known as COVID-19 (WHO). To eradicate severe acute syndrome 2 pandemic, an effective vaccine should be developed. In current study immunoinformatics procedures were employed introduce a novel multi-epitope subunit vaccine. This can activate equally class I II leukocyte antigen antibody...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic involving so far more than 22 million infections and 776,157 deaths. Effective vaccines are urgently needed to prevent SARS-CoV-2 infections. No have yet been approved for licensure by regulatory agencies. Even though host immune responses beginning be unravelled, effective clearance of virus will depend on both ...