نتایج جستجو برای: azoles

تعداد نتایج: 1992  

2015
KRISTINA BEIJER Henner Hollert

Beijer, K. 2015. Azoles and Contaminants in Treated Effluents Interact with CYP1 and CYP19 in Fish. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 1255. 42 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9248-9. Numerous contaminants are present in mixtures in the aquatic environment. Among these are the azoles, a group of chemic...

2016
Jinxing Song Pengfei Zhai Yuanwei Zhang Caiyun Zhang Hong Sang Guanzhu Han Nancy P. Keller Ling Lu

UNLABELLED Ergosterol is a major and specific component of the fungal plasma membrane, and thus, the cytochrome P450 enzymes (Erg proteins) that catalyze ergosterol synthesis have been selected as valuable targets of azole antifungals. However, the opportunistic pathogen Aspergillus fumigatus has developed worldwide resistance to azoles largely through mutations in the cytochrome P450 enzyme Cy...

Journal: :Acta biochimica Polonica 2015
Karolina Gołąbek Joanna Katarzyna Strzelczyk Aleksander Owczarek Piotr Cuber Anna Ślemp-Migiel Andrzej Wiczkowski

A phenomenon of increasing resistance of Candida spp. to azoles has been observed for several years now. One of the mechanisms of lack of sensitivity to azoles is associated with CDR1, CDR2, MRD1 genes (their products are active transport pumps conditioning drug efflux from pathogen's cell), and ERG11 gene (encoding lanosterol 14α-demethylase). Test material was 120 strains of Candida albicans ...

2010
Bryce E. Mansfield Hanna N. Oltean Brian G. Oliver Samantha J. Hoot Sarah E. Leyde Lizbeth Hedstrom Theodore C. White

Despite the wealth of knowledge regarding the mechanisms of action and the mechanisms of resistance to azole antifungals, very little is known about how the azoles are imported into pathogenic fungal cells. Here the in-vitro accumulation and import of Fluconazole (FLC) was examined in the pathogenic fungus, Candida albicans. In energized cells, FLC accumulation correlates inversely with express...

2012
Yun-Liang Yang Chih-Chao Lin Te-Pin Chang Tsai-Ling Lauderdale Hui-Ting Chen Ching-Fu Lee Chih-Wen Hsieh Pei-Chen Chen Hsiu-Jung Lo

Infections caused by treatment-resistant non-albicans Candida species, such as C. tropicalis, has increased, which is an emerging challenge in the management of fungal infections. Genetically related diploid sequence type (DST) strains of C. tropicalis exhibiting reduced susceptibility to fluconazole circulated widely in Taiwan. To identify the potential source of these wildly distributed DST s...

2015
Felipe Queiroga Sarmento Guerra Rodrigo Santos Aquino de Araújo Janiere Pereira de Sousa Fillipe de Oliveira Pereira Francisco J. B. Mendonça-Junior José M. Barbosa-Filho Edeltrudes de Oliveira Lima

Aspergillus spp. produce a wide variety of diseases. For the treatment of such infections, the azoles and Amphotericin B are used in various formulations. The treatment of fungal diseases is often ineffective, because of increases in azole resistance and their several associated adverse effects. To overcome these problems, natural products and their derivatives are interesting alternatives. The...

Journal: :The journal of physical chemistry. A 2015
Charles M Nichols William M Old W Carl Lineberger Veronica M Bierbaum

Making use of the extended kinetic method and the alternative method for data analysis, we have experimentally determined ΔH°acid (kcal/mol) for six mononitrated azole species (2-nitropyrrole = 337.0, 3-nitropyrrole = 335.8, 3-nitropyrazole = 330.5, 4-nitropyrazole = 329.5, 2-nitroimidazole = 327.4, and 4-nitroimidazole = 325.0). We report an absolute uncertainty of ±2.2 kcal/mol that arises fr...

Journal: :Chemical communications 2011
Mingwen Zhu Ken-ichi Fujita Ryohei Yamaguchi

A highly efficient and convenient CuCl/2-pyridonate catalytic system for oxidative homocoupling of azoles affording a biazole product has been developed. With this system, a variety of biazoles have been effectively synthesized in good to excellent yields in the presence of a very small amount of copper catalyst (1.0 mol%). It was feasible to employ air as a green oxidant.

Journal: :Journal of Fungi 2021

Azoles are one of the most widely used drugs to treat fungal infections. To further understand response azoles, we analyzed MAPK circuitry model yeast Saccharomyces cerevisiae that operates under treatment with these antifungals. Imidazoles, and particularly clotrimazole, trigger deeper changes in phosphorylation than triazoles, involving a reduction signaling through mating pathway activation ...

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