The negative ion chemistry of five azine molecules has been investigated using the combined experimental techniques of negative ion photoelectron spectroscopy to obtain electron affinities (EA) and tandem flowing afterglow-selected ion tube (FA-SIFT) mass spectrometry to obtain deprotonation enthalpies (Δ(acid)H(298)). The measured Δ(acid)H(298) for the most acidic site of each azine species is...

A summary of research in the area of fluoroalkylation of electron-deficient aromatic compounds is presented. The reaction of dinitroand cyanonitroarenes with trifluoromethyl-trimethylsilane (Me3SiCF3) and tris(dimethylamino)sulfonium difluorotrimethylsilicate (TASF) and subsequently with DMD provides trifluoromethylated cyanoand nitrophenols via oxidative nucleophilic substitution of hydrogen. ...

The installation of –CF3 or –CF2H groups into compounds can impact important biologically relevant properties. In a recent paper published in Nature, McNally, Paton, and co-workers introduce novel phosphine-based reagents that allow for the conversion variety complex azines through C–H functionalization directly their fluoroalkylated derivatives. Incorporation drug molecules often improve pharm...

Photocatalysis has recently given impetus to the use of ligated boryl radicals (LBRs) in synthesis, thanks mild conditions required for their generation based on visible light. LBRs are B-centered wherein boron atom is coordinated with a suitable Lewis base (e.g., amine, phosphine, or N-heterocyclic carbene [NHC]) and can be conveniently accessed from corresponding boranes through cleavage B−H ...