materials and methods in this experimental study, nmri male mice were placed in groups receiving atropine (0.1 and 1 mg/kg), recipient of mgo-n (1, 2.5, and 5 mg/kg) and groups receiving atropine in effective dose and different doses of mgo-n were used. saline was used as a vehicle for drugs in the control groups. memory was evaluated with a step-down apparatus to determine the coming down late...

introduction: butylated hydroxytoluene (bht 2, 6-di-tert-butyl-p-cresol) is one of the extensively used antioxidants in the food industry. it is used in low-fat foods, fish products, packaging materials, paraffin, and mineral oils. bht is also widely used in combination with other antioxidants such as bha, propyl gallate, and citric acid for the stabilization of oils and high-fat foods. on the ...

In this study, the efficacy of Coriandrum and salvia extracts in spatial and passive avoidance memory in mice was studied. 56 male mice (25-30g) divided randomly into 8 groups: negative control, positive control and extract administered (50, 100 and 200 mg/kg of both plants), and treated for 25 days. negative and positive control group received normal saline and Ritalin respectively. After trai...

background: it has been known that brain-derived neurotrophic factor (bdnf) is involved in neural survival and long term memory (ltm). here we hypothesized that bdnf as a potent neurotrophic factor might modulate amnestic effect induced by morphine. objectives: the aim of this study was to examine whether infusion of exogenous bdnf in the ca1 regions of the dorsal hippocampi could ameliorate me...

diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the humans and experimental animals. due to the anti-diabetic and antioxidant activity of pelargonidin (pg), this research study was conducted to evaluate the efficacy of chronic oral pg on alleviating learning and memory disturbance in streptozotocin-diabetic rats. male wistar rats were divided into...

background: alzheimer’s disease was known as a progressive neurodegenerative disorder in the elderly and is characterized by dementia and severe neuronal loss in the some regions of brain such as nucleus basalis magnocellularis. it plays an important role in the brain functions such as learning and memory. loss of cholinergic neurons of nucleus basalis magnocellularis by ibotenic acid can commo...

Background and Objective: Temporal lobe epilepsy (TLE) usually leads to memory deficit. In this study, we tried to assess the effect of Withania somnifera extract on the impaired learning and memory in the intrahippocampal kainate model of TLE in the rat. Materials & Methods: Male rats (n=32) were divided into sham, extract+sham, kainite, and kainite+extract. For induction of epilepsy, unilate...

Background and Objective: Based on the effect of chronic metabolic diseases including diabetes mellitus on the learning and memory, this study was designed to assess the usefulness of administration of salvialonic acid B on lessening of learning and memory deficits in streptozotocin (STZ)-diabetic rats. Materials and Methods: Male Wistar rats were allocated into control, salvialonic acid B-trea...

In the present study, the effects of morphine sensitization on morphine-induced impairment of memory formation and the state-dependent retrieval of a passive avoidance task learned under morphine influence have been investigated in mice. Pre-training administration of morphine (0.5, 2.5 and 5 mg/kg) dose dependently suppressed the learning of one-trial passive avoidance task. Pre-test administr...

In the present study, the effects of morphine sensitization on morphine-induced impairment of memory formation and the state-dependent retrieval of a passive avoidance task learned under morphine influence have been investigated in mice. Pre-training administration of morphine (0.5, 2.5 and 5 mg/kg) dose dependently suppressed the learning of one-trial passive avoidance task. Pre-test administr...