Avian pneumovirus (APV) causes turkey rhinotracheitis (TRT) and swollen head syndrome (SHS) of chickens, which is usually accompanied by secondary bacterial infections that increase mortality. In Iran, some serological studies indicated that APV infection is endemic in commercial poultry industry. In this study we diagnosed APV genome molecularly in suspected broiler flock (4 weeks) in Iran and...

Avian metapneumovirus (aMPV) is a highly contagious pathogen for broilers. Its epidemiological aspects remain poorly understood in Morocco. Given that, we carried out pilot seroepidemiological survey from December 2020 to June 2021 define aMPV seroprevalence Moroccan broiler flocks different bioclimatic zones (humid sub-humid, semi-arid, arid) during winter and spring. According these zones, 48...

Studies were performed to determine if mucosal vaccination with inactivated avian metapneumovirus (aMPV) subtype C protected turkey poults from clinical disease and virus replication following mucosal challenge. Decreases in clinical disease were not observed in vaccinated groups, and the vaccine failed to inhibit virus replication in the tracheas of 96% of vaccinated birds. Histopathologically...

An avian metapneumovirus (aMPV) virosome vaccine was prepared and tested for protection of turkeys by aMPV challenge. The vaccine was produced using a detergent-based (Triton X-100) extraction of aMPV subtype C followed by detergent removal with SM2 Bio-Beads. Western blot and virus-neutralization analysis confirmed that the aMPV virosomes contained both the fusion and attachment glycoproteins....

Members of the family Paramyxoviridae are pleomorphic enveloped viruses that contain a single-stranded, non-segmented RNA genome of 13-19 kilobases (Lamb and Parks, 2007). These viruses have been isolated from many species of avian, terrestrial and aquatic animals around the world. Some members of the family Paramyxoviridae are well known human (measles, mumps, respiratory syncytial virus and v...

The VII International Symposium on Respiratory Viral Infections was a multidisciplinary forum for the presentation of recent advances in respiratory virus research with special emphasis on antiviral therapies and vaccine strategies. Topics covered in invited lectures included detection of novel respiratory viral pathogens and viral evolution, characterization of the 1918 pandemic virus, human m...

Human metapneumovirus is known to be similar to respiratory syncytial virus. Because of an incomplete protective immune response to new genotypes, re-infection occurs frequently, especially in the elderly. However, the clinical manifestations of human metapneumovirus need to be further characterized in adults. A 73-year-old woman presented to the emergency room with acute dyspnea, chest discomf...

The discovery of human metapneumovirus and its implications for respiratory tract disease have emphasized the need for a sensitive, specific, and rapid assay to detect this virus in a clinical setting. It recently became clear that human metapneumovirus can be grouped into at least four genetic lineages. Previously described assays for the detection of human metapneumovirus were developed by us...