celiac disease (cd) is an autoimmune enteropathy induced by the ingestion of gluten in genetically predisposed individuals who carry the hla dq2 or dq8 alleles. the etiology is multifactorial involving genetic and environmental factors, immune response, and intestinal dysbiosis. the innate and acquired t-cell mediated immunity play important roles in the pathogenesis of this disease, particular...

The term autoimmune enteropathy (AIE) was applied to a form of "intractable diarrhoea" with serum gut autoantibodies, characterized by male predominance, early onset, poor response to parenteral nutrition and several autoimmune diseases, mainly type 1 diabetes. In recent years the vague concept of AIE has became more precise thanks to the discovery of its genetic and molecular basis. The FOXP3 ...

Background Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease characterized by pancreatic beta-cell destruction, hyperglycemia and progressive insulin deficiency, affecting mainly children and adolescents genetically predisposed. About 10% (2.4-16.4%) of T1D individuals develop celiac disease (CD), an immune-mediated enteropathy triggered by gluten exposure. Both diseases have a com...

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a rare, fatal autoimmune disorder caused by mutations in the FOXP3 gene leading to the disruption of signaling pathways involved in regulatory T-lymphocyte function. Lifelong multiagent immunosuppression is necessary to control debilitating autoimmune manifestations such as colitis and food allergies. Allogeneic ...

Gluten-related diseases were recently classified into three groups according to their physiopathological mechanisms: autoimmunity (celiac disease, dermatitis herpetiformis, gluten ataxia), allergy (wheat allergyrespiratory, alimentary, contact urticary and WDEIA) and no-autoimmune no-allergic (gluten sensitivity)(30). Dermatitis herpetiformis (DH) is an autoimmune blistering cutaneous disease t...