Vitiligo is an autoimmune skin disease which is characterized by depigmented patches due to loss of pigment cells. Evidence suggests that cell-mediated immunity plays a role in melanocyte destruction while some patients have antibodies to melanocytes or melanocytic proteins. Vitiligo is strongly associated with a number of autoimmune disorders. Autoimmune thyroiditis is the most prevalent disea...

Pemphigus vulgaris is a blistering autoimmune disease with suprabasal cleft formation, which is the most common autoimmune blistering disease in eastern countries, such as Middle East. Predisposition to pemphigus is linked to genetic factors. Tuberous sclerosis is also a genetic disorder of hamartoma formation in many organs, particularly the skin, brain, eye, kidney and heart. We report ...

conclusions special high-risk groups, including patients with ltbi, should be treated before receiving tnf-α inhibitors. the tuberculin skin test (tst) is a somewhat cost-effective test for the diagnosis of ltbi. however, its usefulness with respect to false results should be re-evaluated in this situation. results there were somewhat different approaches proposed by various researchers regardi...

immunodeficiency and autoimmune disease may occur concomitantly in the same individual. some of the immunodeficiency syndromes, especially humoral defects are associated with autoimmune disorders. hematological manifestations such as thrombocytopenia and hemolytic anemia are the most common presentations. persistent antigen stimulation due to an inherent defect in the ability of the immune syst...

Background The identification of new exploitable molecular pathogeneses (beyond the conventional amyloid hypothesis) for Alzheimer’s disease (AD) is a continuing neurotherapeutic priority, and has yielded range mechanistic proposals including immunopathy, gliopathy, mitochondriopathy, synaptopathy. However, as these hypotheses emerge, they are often regarded mutually exclusive even in competiti...