Fourteen patients with high-risk T-lineage acute lymphoblastic leukemia (ALL) in complete remission underwent autologous bone marrow transplantation (BMT) in an attempt to eradicate their residual disease burden. A combined immunochemotherapy protocol using a cocktail of two immunotoxins directed against CD5/Tp67 and CD7/Tp41 T-lineage differentiation antigens in combination with the in vitro a...

Malignant cells in haemopoietic autografts can contribute to post-transplant relapse. Engraftment of myeloma patients with CD34+ peripheral blood progenitors selected from total autografts reduces the number of tumour cells infused by 2.7-4.5 logs. Residual tumour cells detected in CD34+ selected cells may be due to selection impurity or the existence of malignant CD34+ progenitors. In three pa...

Study Design Prospective, cohort, non-inferiority study. Purpose This study evaluated the clinical and radiological outcomes of interbody fusion using a combination of demineralized bone matrix (DBM) and hydroxyapatite (HA). Overview of Literature The use of autografts remains a gold standard in lumbar interbody fusion, but the limited availability and donor site morbidity encourages the us...

Vascular infiltration and associated alterations in microvascular blood flow are critical for complete bone graft healing. Therefore, real-time, longitudinal measurement of blood flow has the potential to successfully predict graft healing outcomes. Herein, we non-invasively measure longitudinal blood flow changes in bone autografts and allografts using diffuse correlation spectroscopy in a mur...

INTRODUCTION The porpuse of this animal study was to assess chondrocyte apoptosis and MMP-1, MMP-3 and TIMP-2 expression in rabbit tibial cartilage 6 months after viable medial meniscal autografts and allografts. MATERIAL AND METHODS Twenty white male New Zealand rabbits were chosen for the study. The medial meniscus was excised from 14 animals and stored under tissue culture conditions for 2...

Peripheral nerve injury is a common clinical entity, which may arise due to traumatic, tumorous, or even iatrogenic injury in craniomaxillofacial surgery. Despite advances in biomaterials and techniques over the past several decades, reconstruction of nerve gaps remains a challenge. Autografts are the gold standard for nerve reconstruction. Using autografts, there is donor site morbidity, subse...

Autografts from spontaneous cancers of mice when replanted into areas previously exposed to an erythema dose of x-rays, failed to grow in the majority of instances (71.4 per cent), while similar grafts inoculated into untreated areas grew in a large proportion of the animals (83.6 per cent). Autografts of spontaneous cancer, established and growing in the skin, disappeared in 76 per cent of ani...

Cultured epidermal autografts have been used in recent years, despite the difficulty of treating extensive burns. Appropriate wound management after cultured autograft device transfer is also necessary. Physicians must ensure appropriate administration by managing growth microorganisms and meticulously changing patients’ dressings. Moreover, requires a dry environment exposure to air engraftmen...

Abstract Acceptance or rejection of transplanted tissues is dependent upon both genetic and environmental factors. We used guppy fish, Poecilia reticulata, as a model for studying those factors impacting the immune response to scale tissues. Scale tissue acceptance observed when blood has begun circulate throughout grafted can occur at different time intervals due degree difference between dono...