Second cancers and particularly postransplant lymphoproliferative disorders (PTLDs) are extremely rare in patients undergoing autologous peripheral blood stem cell transplantation (auto-SCT). We report the case of clonally rearranged T-cell expansion which occurred after auto-SCT for Multiple Myeloma (MM). Does asymptomatic clonal T-cell large granular lymphocytic proliferation, in our experien...

This paper presents a fuzzy logic, PI, average current controlled shunt active power filter used to compensate for harmonic distortion in three-phase four-wire systems. The shunt active filter employs a simple method for the calculation of the reference compensation current based on Fast Fourier Transform. The presented Shunt Active Power filter is able to operate in balanced, unbalanced and Va...

Developing thymocytes are screened for self-reactivity before exiting the thymus, but how thymocytes scan the medulla for self-antigens is unclear. Using two-photon microscopy, we observed that medullary thymocytes migrated rapidly and made frequent, transient contacts with dendritic cells. In the presence of a negative selecting ligand, thymocytes slowed, became confined to areas of approximat...

Multiple myeloma (MM) is the most common indication for autologous hematopoietic stem cell transplantation (HSCT) in North America. Despite occurring in up to 50% of patients undergoing allogeneic HSCT, the incidence of graft-versus-host disease (GVHD) after autologous HSCT is reportedly only 5-20%. Gastrointestinal involvement with graft-versus-host disease (GI GVHD) is a common and serious co...

Applying highly sensitive modern immune profiling techniques to the blood or inflamed tissue of auto-immune patients with one of the common T-cell mediated diseases fails to detect large clonal expansions or other signs of a dysregulated immune system. Additionally, these new methods have shown that self-reactive Tcells are found in the periphery (and are not completely negatively selected in t...

Pancreas transplantation in type 1 diabetes patients could result in (re)activation of allo- and autoreactive T lymphocytes. Anti-thymocyte globulin (ATG) induction treatment is a successful, but broadly reactive anti-lymphocyte therapy used in pancreas and islet transplantation. A more selective alternative is daclizumab, a monoclonal antibody directed against the interleukin-2 receptor (CD25)...

Autoimmune Diseases (ADs) are diseases in which the immune system mistakenly attacks and destroys selfmolecules due to a disruption of immunologic tolerance to auto-reactive immune cells. The goals of treatments for ADs are to 1) reduce symptoms, 2) control the autoimmune process and 3) maintain the body’s ability to fight disease. Allogenic Hematopoietic Stem Cell (HSC) transplantation has bee...

background and objectives: auto-induction is usually employed to achieve high cell density and overproduction of proteins with a simple and low-cost operation. the efficiency of heterologous protein expression in escherichia coli is determined by different parameters. interactions between these parameters usually complicate the identification of those that contribute more to the improvement of ...

Security of information is of utmost importance to any organization or individual, which depend on computer system or internet for business transaction or source of information or research. Many viruses are able to recognize certain anti-virus software, and respond differently to such software than to programs designed for other purposes. Some viruses go after the databases stored by anti-virus...